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. 2019 Apr;25(7-8):603-619.
doi: 10.1089/ten.TEA.2018.0175. Epub 2018 Nov 10.

Amnion-Based Scaffold with Enhanced Strength and Biocompatibility for In Vivo Vascular Repair

Megan M Swim  1 , Ambra Albertario  1 , Dominga Iacobazzi  1 , Massimo Caputo  1 , Mohamed T Ghorbel  1
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Amnion-Based Scaffold with Enhanced Strength and Biocompatibility for In Vivo Vascular Repair

Megan M Swim et al. Tissue Eng Part A. 2019 Apr.

Abstract

This study aimed at developing an amnion-based scaffold suitable for vascular tissue engineering applications and in vivo usage. We successfully produced a multilayered scaffold with improved biomechanical properties and biocompatibility for in vivo vascular implantation. Our approach not only offers an allogeneic "off-the-shelf" solution for clinical use but also it provides the possibility of personalized medicine using a patient's own amnion and stem cells for the production of tissue engineered grafts for reconstructive heart surgery.

Keywords: amnion; corrective heart surgery; decellularization; mesenchymal stem cells; tissue engineering.

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