Amnion-Based Scaffold with Enhanced Strength and Biocompatibility for In Vivo Vascular Repair

Abstract

This study aimed at developing an amnion-based scaffold suitable for vascular tissue engineering applications and in vivo usage. We successfully produced a multilayered scaffold with improved biomechanical properties and biocompatibility for in vivo vascular implantation. Our approach not only offers an allogeneic "off-the-shelf" solution for clinical use but also it provides the possibility of personalized medicine using a patient's own amnion and stem cells for the production of tissue engineered grafts for reconstructive heart surgery.

Keywords: amnion; corrective heart surgery; decellularization; mesenchymal stem cells; tissue engineering.