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. 2018 Sep;33(3):e2018014-0.
doi: 10.5620/eht.e2018014. Epub 2018 Sep 28.

A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals

Ha Ryong Kim  1 , Da Young Shin  2 , Kyu Hyuck Chung  2
Affiliations

A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals

Ha Ryong Kim et al. Environ Health Toxicol. 2018 Sep.

Abstract

Several studies showed that the inflammatory and fibrotic responses induced by polyhexamethylene guanidine phosphate (PHMG-p) were similar to those observed for idiopathic pulmonary fibrosis in South Korea in 2011. "Omic" technologies can be used to understand the mechanisms underlying chemical-induced diseases. Studies to determine the toxicity of chemicals may facilitate understanding of the mechanisms underlying the development of pulmonary fibrosis at a molecular level; thus, such studies may provide information about the toxic characteristics of various substances. In this review, we have outlined the cellular and molecular mechanisms underlying idiopathic pulmonary fibrosis and described pulmonary fibrosis induced by various chemicals, including bleomycin, paraquat, and PHMG-p, based on the results of studies performed to date.

Keywords: epithelial cell; microRNA; polyhexamethylene guanidine phosphate (PHMG-p); pulmonary fibrosis.

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Conflict of interest statement

The authors have no conflicts of interest associated with the material presented in this paper.

Figures

Figure 1.
Figure 1.
Putative mechanisms of fibrogenesis induced by PHMG-p based on the cellular responses and miRNA microarray analysis.
See this image and copyright information in PMC

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