. 2018 Oct 4;18(1):102.

doi: 10.1186/s12874-018-0560-4.

A transdisciplinary team approach to scoping reviews: the case of pediatric polypharmacy

Paul M Bakaki¹, Jennifer Staley², Rujia Liu³, Neal Dawson^{3

4}, Negar Golchin⁵, Alexis Horace⁶, Hannah Johnson³, Jennifer Waldron^{2

7}, Almut Winterstein⁸, Lawrence C Kleinman^{2

7

9}, Shari D Bolen^{3

4

10}

Affiliations

¹ Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA. pmb18@case.edu.
² Rainbow Babies and Children's Hospital, University Hospitals, Cleveland, OH, USA.
³ Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
⁴ Department of Medicine, MetroHealth Medical Center, Cleveland, OH, USA.
⁵ School of Pharmacy, University of Washington, Seattle, WA, USA.
⁶ Department of Clinical Sciences, University of Louisiana at Monroe College of Pharmacy, Monroe, LA, USA.
⁷ School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
⁸ College of Pharmacy, University of Florida, Gainesville, FL, USA.
⁹ The Center for Child Health and Policy at Rainbow, University Hospitals, Cleveland, OH, USA.
¹⁰ Center for Health Care Research and Policy, Case Western Reserve University at the MetroHealth System, Cleveland, OH, USA.

PMID: 30286720
PMCID: PMC6172739
DOI: 10.1186/s12874-018-0560-4

A transdisciplinary team approach to scoping reviews: the case of pediatric polypharmacy

Paul M Bakaki et al. BMC Med Res Methodol. 2018.

. 2018 Oct 4;18(1):102.

doi: 10.1186/s12874-018-0560-4.

Authors

Affiliations

¹ Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA. pmb18@case.edu.
² Rainbow Babies and Children's Hospital, University Hospitals, Cleveland, OH, USA.
³ Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
⁴ Department of Medicine, MetroHealth Medical Center, Cleveland, OH, USA.
⁵ School of Pharmacy, University of Washington, Seattle, WA, USA.
⁶ Department of Clinical Sciences, University of Louisiana at Monroe College of Pharmacy, Monroe, LA, USA.
⁷ School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
⁸ College of Pharmacy, University of Florida, Gainesville, FL, USA.
⁹ The Center for Child Health and Policy at Rainbow, University Hospitals, Cleveland, OH, USA.
¹⁰ Center for Health Care Research and Policy, Case Western Reserve University at the MetroHealth System, Cleveland, OH, USA.

PMID: 30286720
PMCID: PMC6172739
DOI: 10.1186/s12874-018-0560-4

Abstract

Background: Polypharmacy can be either beneficial or harmful to children. We conducted a scoping review to examine the concept of pediatric polypharmacy: its definition, prevalence, extent and gaps in research. In this manuscript, we report our transdisciplinary scoping review methodology.

Methods: After establishing a transdisciplinary team, we iteratively developed standard operating procedures for the study's search strategy, inclusion/exclusion criteria, screening, and data extraction. We searched eight bibliographic databases, screened abstracts and full text articles, and extracted data from included studies using standardized forms. We held regular team meetings and performed ongoing internal validity measurements to maintain consistent and quality outputs.

Results: With the aid of EPPI Reviewer collaborative software, our transdisciplinary team of nine members performed dual reviews of 363 included studies after dual screening of 4398 abstracts and 1082 full text articles. We achieved overall agreement of 85% and a kappa coefficient of 0.71 (95% CI 0.68-0.74) while screening full text articles. The screening and review processes required about seven hours per extracted study. The two pharmacists, an epidemiologist, a neurologist, and a librarian on the review team provided internal consultation in these key disciplines. A stakeholder group of 10 members with expertise in evidence synthesis, research implementation, pediatrics, mental health, epilepsy, pharmacoepidemiology, and pharmaceutical outcomes were periodically consulted to further characterize pediatric polypharmacy.

Conclusions: A transdisciplinary approach to scoping reviews, including internal and external consultation, should be considered when addressing complex cross-disciplinary questions.

Keywords: Collaborative research; Pediatric polypharmacy; Scoping review; Team science; Transdisciplinary research.

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Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

**Fig. 1**
The Pediatric Polypharmacy *Transdiscipline* Schema. Implementation Team: Alexis Horace (AH), Courtney Baker (CB), Hannah Johnson (HJ), Jennifer Staley (JS), Jennifer Waldron (JW), Negar Golchin (NG), Paul Bakaki (PB), Rujia Liu (RL), Shari Bolen (SB), Xuan Ma (XM). Protocol Team: Almut Winterstein (AW), Larry Kleinman (LK), Neal Dawson (ND). Stakeholders/Consultants: Cynthia Fontanella (CF), Elia Pestana (EP), Faye Gary (FG), James Feinstein (JF), Joseph Calabrese (JC), Mai Pham (MF), Sharon Meropol (SM)

See this image and copyright information in PMC

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A transdisciplinary team approach to scoping reviews: the case of pediatric polypharmacy

Affiliations

A transdisciplinary team approach to scoping reviews: the case of pediatric polypharmacy

Authors

Affiliations

Abstract

Conflict of interest statement

Ethics approval and consent to participate

Consent for publication

Competing interests

Publisher’s Note

Figures

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Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical