Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Oct 4;20(1):226.
doi: 10.1186/s13075-018-1708-7.

The frequency of ANCA-associated vasculitis in a national database of hospitalized patients in China

Jiannan Li  1 , Zhao Cui  1 , Jian-Yan Long  2 , Wei Huang  3 , Jin-Wei Wang  1 , Haibo Wang  2   4 , Luxia Zhang  1   5 , Min Chen  1 , Ming-Hui Zhao  6   7
Affiliations

The frequency of ANCA-associated vasculitis in a national database of hospitalized patients in China

Jiannan Li et al. Arthritis Res Ther. .

Abstract

Background: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a group of life-threatening autoimmune diseases. The epidemiological data on AAV in China are limited. The aim of the present study is to investigate the frequency, geographical distribution, and ethnic distribution of AAV in hospitalized patients in China, and its association with environmental pollution.

Methods: We investigated the hospitalized patients in a national inpatient database covering 54.1% tertiary hospitals in China from 2010 to 2015. Diagnosis of AAV was extracted according to the definition of International Classification of Diseases (ICD)-10 codes and free text. Variables from the front page of inpatient records were collected and analyzed, including frequency, geographic distribution, demographic characteristics and seasonal variations of AAV. The association between various environmental pollutants and frequency of AAV was further analyzed.

Results: Among 43.7 million inpatients included in the study period, 0.25‰ (10,943) were diagnosed as having AAV. The frequency of AAV was relatively stable during the study period (from 0.34‰ in 2010 to 0.27‰ in 2015). The proportion of AAV increased with latitude (0.44‰ in Northern China and 0.27‰ in Southern China in 2015). Hospitalizations were mostly observed in winter (30.2%). The Dong population, an ethnic minority of the Chinese population, had the highest frequency of patients with AAV (0.67‰). We also found a positive association between the exposure to carbon monoxide and the frequency of AAV (R2 = 0.172, p = 0.025). In Yunnan province, the frequency of AAV increased 1.37-fold after the Zhaotong earthquake, which took place in 2014.

Conclusions: Our present investigation of hospitalized patients provided epidemiological information on AAV in China for the first time. A spatial and ethnic clustering trend and an association between pollution and the frequency of AAV were observed.

Keywords: ANCA; Frequency; Hospitalized population; Vasculitis.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

The research was approved by the clinical research ethics committee of the Peking University First Hospital. All patients provided written informed consent including consent to publish and report individual patient data.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
The distribution of anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV) in different seasons in 2015. The highest frequency of admissions for AAV were in winter (30.2%)
Fig. 2
Fig. 2
The age distribution of anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV) in 2015. Most patients with AAV were older than 50 years, with a peak age at 61–70 years (29.9%)
Fig. 3
Fig. 3
The distribution of anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV) according to Chinese geographical regions in 2015. The frequency of AAV in all inpatients in seven geographical regions, with the highest in North China (0.44‰)
Fig. 4
Fig. 4
Ethnic distribution of anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV) in the Chinese population. The Dong, Zhuang and Li ethnic minorities had the highest frequencies of AAV, with a frequency of 0.67‰, 0.61‰ and 0.42‰, respectively. HQMS, Hospital Quality Monitoring System
Fig. 5
Fig. 5
The proportion of anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV) in Yunnan province and the national average value since 2013. The frequency of AAV in Yunnan province has increased annually since 2013
See this image and copyright information in PMC

References

    1. Furuta S, Jayne DRW. Antineutrophil cytoplasm antibody-associated vasculitis: recent developments. Kidney Int. 2013;84:244–249. doi: 10.1038/ki.2013.24. - DOI - PubMed
    1. Goupil R, Brachemi S, Nadeau-Fredette A-C, Déziel C, Troyanov Y, Lavergne V, Troyanov S. Lymphopenia and treatment-related infectious complications in ANCA-associated vasculitis. Clin J Am Soc Nephrol. 2013;8:416–423. doi: 10.2215/CJN.07300712. - DOI - PMC - PubMed
    1. Koldingsnes W, Jacobsen EA, Sildnes T, Hjalmarsen A, Nossent HC. Pulmonary function and high-resolution CT findings five years after disease onset in patients with Wegener's granulomatosis. Scand J Rheumatol. 2005;34:220–228. doi: 10.1080/03009740410011271. - DOI - PubMed
    1. Cartin-Ceba R, Diaz-Caballero L, Alqadi MO, Tryfon S, Fervenza FC, Ytterberg SR, Specks U. Diffuse alveolar hemorrhage secondary to ANCA-associated vasculitis: predictors of respiratory failure and clinical outcomes. Arthritis Rheumatol 2016;68(6):1467–76. - PubMed
    1. Bligny D, Mahr A, Toumelin PL, Mouthon L, Guillevin L. Predicting mortality in systemic Wegener's granulomatosis: a survival analysis based on 93 patients. Arthritis Rheum. 2004;51:83–91. doi: 10.1002/art.20082. - DOI - PubMed

Publication types

MeSH terms