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Review
. 2018 Oct 9;72(15):1829-1844.
doi: 10.1016/j.jacc.2018.07.081.

Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series

Peter E H Schwarz  1 , Patrick Timpel  2 , Lorenz Harst  3 , Colin J Greaves  4 , Mohammed K Ali  5 , Jeffrey Lambert  6 , Mary Beth Weber  5 , Mohamad M Almedawar  7 , Henning Morawietz  8
Affiliations
Review

Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series

Peter E H Schwarz et al. J Am Coll Cardiol. .

Abstract

The primary objective of this study was to analyze the most up-to-date evidence regarding whether and how blood sugar regulation influences cardiovascular health promotion and disease prevention by carrying out an umbrella review. Three separate, systematic literature searches identified 2,343 papers in total. Overall, 44 studies were included for data extraction and analysis. The included systematic reviews and meta-analyses published between January 1, 2016, and December 31, 2017, were of good to very good quality (median Overview Quality Assessment Questionnaire score = 17). Identified evidence suggests that cardiovascular disease (CVD) prevention services should consider regulation of blood glucose as a key target for intervention. Furthermore, the recommendations for effective intervention and service development/training described here for prevention of CVD should be adopted into evidence-based practice guidelines. Multidisciplinary teams should be formed to deliver multicomponent interventions in community-based settings. There may be substantial opportunities for integrating CVD and diabetes prevention services.

Keywords: blood glucose; diabetes mellitus; diet; exercise; health behavior; umbrella review; weight loss.

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Figures

FIGURE 1:
FIGURE 1:. PRISMA Flow Chart of study selection process
PRISMA Flow Chart shows the study selection process covering the single steps of identification via two-step-screening (title and abstract as well as full text base) for eligibility and inclusion into qualitative synthesis of this review.
FIGURE 2:
FIGURE 2:. Blood Sugar Regulation: Logic Order and Interdependencies
Cardiovascular disease (CVD) risk is influenced by blood glucose regulation, and both CVD risk and blood glucose regulation are influenced by interventions targeting pathophysiological mechanisms (1a, 1b). Other risk factors also affect CVD risk. Blood glucose regulation and other risk factors are, in turn, influenced by changes in behavioral risk factors. Population-level (3a, 3b) and individual-level (2a, 2b) interventions and intervention components influence the behavioral risk factors, influencing blood glucose regulation and, ultimately, CVD risk. Boxes represent the objectives of the individual review sections; arrows show the interdependencies of the objectives for their contribution to the explanation of CVD risk.
See this image and copyright information in PMC

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References

    1. International Diabetes Federation. IDF Diabetes Atlas, 8th edn. Brussels, Belgium: International Diabetes Federation, 2017.
    1. Lozano R, Naghavi M, Foreman K et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012;380:2095–128. - PMC - PubMed
    1. Wilkins E, Wilson L, Wickramasinghe K, Bhatnagar P, Rayner M, Townsend N. European Cardiovascular Disease Statistics 2017. Brussels: European Heart Network, 2017.
    1. Seuring T, Archangelidi O, Suhrcke M. The Economic Costs of Type 2 Diabetes: A Global Systematic Review. PharmacoEconomics 2015;33:811–831. - PMC - PubMed
    1. Hong KN, Fuster V, Rosenson RS, Rosendorff C, Bhatt DL. How Low to Go With Glucose, Cholesterol, and Blood Pressure in Primary Prevention of CVD. J Am Coll Cardiol 2017;70:2171–2185. - PubMed

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