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Editorial
. 2018 Oct 4;6(3):405-407.
doi: 10.9745/GHSP-D-18-00336. Print 2018 Oct 3.

New Evidence on Carbetocin: Another Arrow in Our Quiver

Affiliations
Editorial

New Evidence on Carbetocin: Another Arrow in Our Quiver

Steve Hodgins. Glob Health Sci Pract. .

Abstract

Carbetocin is more heat stable than oxytocin with at least equivalent efficacy for preventing postpartum hemorrhage. It will certainly be helpful if the supplier can make it available in low-income country settings at a price comparable to oxytocin. But even so, programs will still need oxytocin and other uterotonic medications.

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  • Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth.
    Widmer M, Piaggio G, Nguyen TMH, Osoti A, Owa OO, Misra S, Coomarasamy A, Abdel-Aleem H, Mallapur AA, Qureshi Z, Lumbiganon P, Patel AB, Carroli G, Fawole B, Goudar SS, Pujar YV, Neilson J, Hofmeyr GJ, Su LL, Ferreira de Carvalho J, Pandey U, Mugerwa K, Shiragur SS, Byamugisha J, Giordano D, Gülmezoglu AM; WHO CHAMPION Trial Group. Widmer M, et al. N Engl J Med. 2018 Aug 23;379(8):743-752. doi: 10.1056/NEJMoa1805489. Epub 2018 Jun 27. N Engl J Med. 2018. PMID: 29949473 Clinical Trial.

References

    1. Widmer M, Piaggio G, Nguyen TMH, et al. ; WHO CHAMPION Trial Group. Heat-stable carbetocin versus oxytocin to prevent hemorrhage after vaginal birth. N Engl J Med. 2018;379(8):743–752. 10.1056/NEJMoa1805489. - DOI - PubMed
    1. Mundasad S. Revamped drug could save lives of many new mothers – WHO. BBC News. June 28, 2018. https://www.bbc.com/news/world-asia-44617525. Accessed September 10, 2018.
    1. Meshykhi LS, Nel MR, Lucas DN. The role of carbetocin in the prevention and management of postpartum haemorrhage. Int J Obstet Anesth. 2016;28:61–69. 10.1016/j.ijoa.2016.10.003. - DOI - PubMed
    1. Hogerzeil HV, Walker GJA, de Goeje MJ. Stability of Injectable Oxytocics in Tropical Climates: Results of Field Surveys and Simulation Studies on Ergometrine, Methylergometrine and Oxytocin. Geneva: World Health Organization; 1993. http://apps.who.int/medicinedocs/en/d/Js2205e/. Accessed September 10, 2018.
    1. Stanton C, Koski A, Cofie P, Mirzabagi E, Grady BL, Brooke S. Uterotonic drug quality: an assessment of the potency of injectable uterotonic drugs purchased by simulated clients in three districts in Ghana. BMJ Open. 2012;2(3):pii: e000431. 10.1136/bmjopen-2011-000431. - DOI - PMC - PubMed

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