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. 2018;20(2):63-68.
doi: 10.3909/riu0798.

Effectiveness of Subcutaneously Administered Leuprolide Acetate to Achieve Low Nadir Testosterone in Prostate Cancer Patients

Christopher M Pieczonka  1 , Przemyslaw Twardowski  2 , Joseph Renzulli 2nd  3 , Jason Hafron  4 , Deborah M Boldt-Houle  5 , Stuart Atkinson  5 , Scott Eggener  6
Affiliations

Effectiveness of Subcutaneously Administered Leuprolide Acetate to Achieve Low Nadir Testosterone in Prostate Cancer Patients

Christopher M Pieczonka et al. Rev Urol. 2018.

Erratum in

Abstract

Evidence suggests lower nadir testosterone levels during the first year of androgen deprivation therapy improve advanced prostate cancer clinical outcomes. We evaluated pivotal trials for subcutaneously administered leuprolide acetate (1-, 3-, 4-, and 6-month doses) to determine nadir testosterone levels. Pooled analysis showed 99%, 97%, and 91% of patients reached nadir testosterone ≤20, ≤10, and ≤5 ng/dL respectively (median ≤3 ng/dL). Across all available categories, $88% of patients reached nadir testosterone ≤5 ng/dL, and <3% experienced a microsurge. Achievement and maintenance of low nadir testosterone levels may improve progression-free survival and time to onset of castrate-resistant prostate cancer.

Keywords: Androgen deprivation therapy; LHRH agonist; Leuprolide acetate; Nadir testosterone; Prostate cancer.

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Figures

Figure 1
Figure 1
(A) Median time to testosterone ≤10, ≤20, or ≤50 ng/dL. (B) Proportion of time testosterone levels maintained ≤10, ≤20, or ≤50 ng/dL.
Figure 2
Figure 2
Proportion of time testosterone below suppression target* (illustrative for T ≤20 ng/dL). *Proportion of time below target calculated by dividing the total time below target by the time after target first achieved.
Figure 3
Figure 3
Proportion of patients by nadir testosterone level achieved over study duration (n = 437).
See this image and copyright information in PMC

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