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. 2018 Oct;60(10):911-916.
doi: 10.1097/JOM.0000000000001387.

Organochlorine Levels in Plasma and Risk of Multiple Myeloma

Leah Weber  1 , Kevin Song, Terry Boyle, Éric Gaudreau, Agnes Lai, Heather J Sutherland, Alain LeBlanc, John J Spinelli
Affiliations

Organochlorine Levels in Plasma and Risk of Multiple Myeloma

Leah Weber et al. J Occup Environ Med. 2018 Oct.

Abstract

Objective: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM).

Methods: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls.

Results: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio = 7.44; 95% confidence interval = 4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and β-hexachlorocyclohexane (β-HCCH) were identified as significant independent predictors of MM.

Conclusion: Our study provides evidence that organochlorines contribute to the risk of MM.

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