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Comment
. 2018 Oct 4;23(4):459-460.
doi: 10.1016/j.stem.2018.09.002.

Hematopoietic Stem Cells Rock Around The Clock: Circadian Fate Control via TNF/ROS Signals

James S Chavez  1 , Eric M Pietras  2
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Comment

Hematopoietic Stem Cells Rock Around The Clock: Circadian Fate Control via TNF/ROS Signals

James S Chavez et al. Cell Stem Cell. .
Free article

Abstract

Hematopoietic stem cell function is closely tied to circadian rhythms. In this issue of Cell Stem Cell, Golan et al. (2018) identify crosstalk between circadian hormone signals, the inflammatory cytokine TNF, and bone marrow macrophages as a key regulator of HSC proliferation, differentiation, and self-renewal in the bone marrow.

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  • Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.
    Golan K, Kumari A, Kollet O, Khatib-Massalha E, Subramaniam MD, Ferreira ZS, Avemaria F, Rzeszotek S, García-García A, Xie S, Flores-Figueroa E, Gur-Cohen S, Itkin T, Ludin-Tal A, Massalha H, Bernshtein B, Ciechanowicz AK, Brandis A, Mehlman T, Bhattacharya S, Bertagna M, Cheng H, Petrovich-Kopitman E, Janus T, Kaushansky N, Cheng T, Sagi I, Ratajczak MZ, Méndez-Ferrer S, Dick JE, Markus RP, Lapidot T. Golan K, et al. Cell Stem Cell. 2018 Oct 4;23(4):572-585.e7. doi: 10.1016/j.stem.2018.08.002. Epub 2018 Aug 30. Cell Stem Cell. 2018. PMID: 30174297

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