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Comment
. 2018 Oct 4;23(4):464-465.
doi: 10.1016/j.stem.2018.09.011.

New Recipes for Myelinating Oligodendrocytes

Hiroko Nobuta  1 , John H Stockley  2 , David H Rowitch  3
Affiliations
Comment

New Recipes for Myelinating Oligodendrocytes

Hiroko Nobuta et al. Cell Stem Cell. .

Abstract

While myelinating oligodendrocytes are attractive candidates for cell-based regenerative therapies, producing them in adequate quantities and regulation of progenitor differentiation pathways has proven limiting. Recently, Hubler et al. (2018) and Madhavan et al. (2018) generated cerebral organoids with myelinating oligodendrocytes and manipulated sterol pathway small molecules to promote myelin synthesis.

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  • Induction of myelinating oligodendrocytes in human cortical spheroids.
    Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ. Madhavan M, et al. Nat Methods. 2018 Sep;15(9):700-706. doi: 10.1038/s41592-018-0081-4. Epub 2018 Jul 25. Nat Methods. 2018. PMID: 30046099 Free PMC article.
  • Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.
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