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Case Reports
. 2018 Oct;97(40):e12668.
doi: 10.1097/MD.0000000000012668.

Inflammatory myofibroblastic lung tumor transforming into intracranial desmoplastic noninfantile ganglioglioma: A case report and literature review

Fu Wei  1 , Seidu A Richard  1   2 , Junya Tan  3 , Zhigang Lan  1 , Yan Ju  1
Affiliations
Case Reports

Inflammatory myofibroblastic lung tumor transforming into intracranial desmoplastic noninfantile ganglioglioma: A case report and literature review

Fu Wei et al. Medicine (Baltimore). 2018 Oct.

Abstract

Rationale: Inflammatory myofibroblastic tumor (IMT) of the lung often arises from excessive inflammatory response. It is one of the rare benign tumors of the lung, while desmoplastic noninfant gangliogliomas (DNIG), on the contrary, are rare intracranial benign tumors often seen in children within the first one and a half years of life.

Patient concerns: We present a 12-year-old girl with 2 months history of none productive cough and right-sided chest pain.

Diagnoses: Computer tomography scan of the chest revealed a soft tissue mass at the right upper lobe which was consistent with IMT. Histopathologic examination confirmed the diagnosis of IMT.

Interventions: Thoracic surgery was successfully carried out and she further received radiotherapy. The patient recovered initially.

Outcomes: Two years later, she complained of seizures during follow-up. Magnetic resonance imaging of the head revealed DNIG. We achieved total resection of the major lesions and she was further treated with radiotherapy. She is currently well and in school. Histopathologic examination confirmed the diagnosis of DNIG.

Lesions: We speculate that IMT might have transformed into intracranial DNIG through metastatic process or as a result of genetic mutations or chromosomal abrasions.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
(A–D) Computed tomography scan images showing a large lesion in right upper lobe with extensions into the mediastinum as well as significant compression on the right upper bronchus.
Figure 2
Figure 2
(A–F) Magnetic resonance imaging showing multiple solid tumors sporadically located in the bilateral cerebral hemisphere.
Figure 3
Figure 3
Hematoxylin and eosin findings indicated tumor showing a desmoplastic spindle cell tumor with densely eosinophilic collagenous (A, ×200). Immunohistochemical stain confirmed the positive expression of GFAP (B, ×400), Synaptophysin (C, ×400), and Oligo2 (D, ×400). GFAP = glial fibrillary acid protein.
See this image and copyright information in PMC

References

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