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Comment
. 2018 Oct;4(10):657-659.
doi: 10.1016/j.trecan.2018.06.001. Epub 2018 Sep 25.

Lighting Up Cancer Dynamics

Pavithran T Ravindran  1 , Maxwell Z Wilson  2
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Free article
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Lighting Up Cancer Dynamics

Pavithran T Ravindran et al. Trends Cancer. 2018 Oct.
Free article

Abstract

Live-cell microscopy has revealed that signaling pathways carry elaborate time-varying activities. Yet, the connection between these dynamics and cellular disease has remained elusive. Recent work leverages cellular optogenetics to analyze the Ras-to-Erk transfer function in cancer cells. These analyses reveal how changes to the filtering properties of a pathway lead to the misperception of extracellular events. Overall, these studies suggest that mutations do not simply hyperactivate pathways but rather can also change their transmission properties in more subtle ways.

Keywords: MAP kinase; cancer; cellular optogenetics; signaling dynamics.

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