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Comment
. 2018 Nov;24(11):917-918.
doi: 10.1016/j.molmed.2018.09.003. Epub 2018 Oct 3.

Senescent Cells Drive Frailty through Systemic Signals

Johannes Lehmann  1 , Marjolein P Baar  1 , Peter L J de Keizer  2
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Comment

Senescent Cells Drive Frailty through Systemic Signals

Johannes Lehmann et al. Trends Mol Med. 2018 Nov.

Abstract

Senescent cells drive ageing and the associated loss in health and lifespan. Whether this is mediated by systemic signalling remained unclear. Recently, Xu et al. [1] (Nat. Med. 2018;24:1246-1256) answered this question by injecting senescent cells into young mice and observing a long-lasting increase in frailty and mortality.

Keywords: SASP; ageing; cellular senescence; frailty; paracrine; systemic.

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  • Senolytics improve physical function and increase lifespan in old age.
    Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Xu M, et al. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988130 Free PMC article.

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