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. 1987 Mar 1;165(3):650-6.
doi: 10.1084/jem.165.3.650.

In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection

M J Reddehase, W Mutter, U H Koszinowski

In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection

M J Reddehase et al. J Exp Med. .

Abstract

We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that in vivo application of recombinant human IL-2 (rhIL-2) can enhance the antiviral effect of a limited number of CD8+T lymphocytes, not only in prophylaxis, but also in therapy, when virus has already colonized host tissues. The observed net effect of IL-2 was consistent with the assumption of daily effector population doublings. The prospects for IL-2-supported immunotherapy of established CMV infection depend upon the tissues involved in disease. It appears that the prospects for controlling established CMV adrenalitis are less promising than for a therapy of interstitial CMV pneumonia.

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