Enhancement in Iron Absorption on Intake of Chemometrically Optimized Ratio of Probiotic Strain Lactobacillus plantarum 299v with Iron Supplement Pearl Millet

Abstract

This research article aims to establish the intake ratio of probiotic Lactobacillus plantarum 299v with iron supplement pearl millet by central composite design of response surface methodology so as to enhance iron absorption. In anemic rat models, the food intake pattern, body weight, hemoglobin content, and hematocrit values were found to be significantly increased on treatment with pearl millet:probiotic; however, incorporation of probiotics at lower dose (0.5 g) was significantly (p < 0.05) effective in enhancing iron absorption, and further increment in probiotic doses (1.0 g) did not produce significant increase in hemoglobin and hematocrit values as evidenced by the experimental findings.

Keywords: Anemia; Central composite design; Iron absorption; Pearl millet; Probiotic.