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Review
. 2018 Sep;47(9):804-810.
doi: 10.1016/j.lpm.2018.09.003. Epub 2018 Oct 4.

[Place of natriuretic peptides in the early diagnosis of heart failure in community medicine]

[Article in French]
Michel Galinier  1 , Eve Cariou  2 , Olivier Lairez  3 , Pauline Fournier  2 , Clément Delmas  4 , Caroline Biendel-Picquet  2 , Jérôme Roncalli  4
Affiliations
Review

[Place of natriuretic peptides in the early diagnosis of heart failure in community medicine]

[Article in French]
Michel Galinier et al. Presse Med. 2018 Sep.

Abstract

Diagnosis of heart failure is too late. Symptoms of heart failure are non-specific. Brain natriuretic peptides allow the diagnosis of heart failure in pauci-symptomatic patients, with a threshold of 35pg/mL for BNP and 125pg/mL for NT-proBNP. Left ventricular dysfunction, either diastolic or systolic, remains asymptomatic for a long time. In diabetic and/or hypertensive patients, natriuretic peptides, can be used to diagnose asymptomatic left ventricular dysfunction, with a threshold of 125pg/mL NT-proBNP. Treatment blocking the renin-angiotensin-aldosterone system in diabetic patients with NT-proBNP levels of 125pg/mL can prevent onset of heart failure. Screening of subjects at risk of heart failure (diabetics, hypertensive) is possible thanks to natriuretic peptides.

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