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. 2018;54(1):25.
doi: 10.1186/s41983-018-0026-y. Epub 2018 Sep 15.

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

Rania S Nageeb  1 , Noha A Hashim  1 , Amal Fawzy  2
Affiliations

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

Rania S Nageeb et al. Egypt J Neurol Psychiatr Neurosurg. 2018.

Abstract

Background: Multiple sclerosis (MS) is a chronic demyelinating central nervous system (CNS) disease. Changes in insulin growth factor 1 (IGF-1) input to the brain can affect survival of myelin and CNS cells. The study aims to investigate the relation of serum IGF-1 levels with cognitive impairment and fatigue in MS patients.

Methods: This study was conducted on 46 MS patients and 46 healthy controls. All participants were subjected to clinical assessment, serum IGF-1 levels, expanded disability status scale (EDSS), modified fatigue impact scale (MFIS), and Montreal cognitive assessment (MoCA) scale.

Results: There was no significant difference between patients and controls regarding serum IGF-1 levels (P = 0.19). However, low serum levels of IGF-1 have significantly greater odds for fatigue (P = 0.002) and cognitive impairment (P < 0.001). Also, serum IGF-1 levels have a significant negative correlation with MFIS (r = - 0.701 and P < 0.001) and a significant positive correlation with MoCA scale (r = + 0.84 and P < 0.001).

Conclusions: The results, specifically that low levels of serum IGF-1 was associated with cognitive impairment and fatigue in MS, suggest that IGF-I may be involved in the pathogenesis of cognitive deficits and fatigue in MS disease.

Keywords: Cognitive impairment; Fatigue; Insulin-like growth factor-1; Multiple sclerosis.

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Conflict of interest statement

The study was approved from the Institutional Ethics Committee of the Faculty of Medicine, Zagazig University (ZU-IRB#4730\ 24-12-2017). A written consent was taken from all of the participants after explaining the details and benefits as well as risks to them.Consent has been obtained from the participants involved in the study to report their individual patient data.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Correlation coefficient of variables with serum levels of IGF-1 in MS patients
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