doi: 10.1128/JVI.61.4.1291-1295.1987.
Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus
- PMID: 3029427
- PMCID: PMC254097
- DOI: 10.1128/JVI.61.4.1291-1295.1987
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Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus
J Virol.
1987 Apr.
Abstract
Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.
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