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. 1987 Apr;61(4):1291-5.
doi: 10.1128/JVI.61.4.1291-1295.1987.

Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus

R T D'Aquila, W C Summers

Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus

R T D'Aquila et al. J Virol. 1987 Apr.

Abstract

Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.

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References

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