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Case Reports
. 2018 Oct 6;6(11):477-482.
doi: 10.12998/wjcc.v6.i11.477.

Isolated myeloid sarcoma in the pancreas and orbit: A case report and review of literature

Ting Zhu  1 , Xu-Yan Xi  2 , Hong-Juan Dong  3
Affiliations
Case Reports

Isolated myeloid sarcoma in the pancreas and orbit: A case report and review of literature

Ting Zhu et al. World J Clin Cases. .

Abstract

Myeloid sarcoma (MS) is a type of extramedullary solid haematological tumour. Myeloid sarcoma is classified into two types based on whether onset of the disease is complicated by haematologic diseases: extramedullary infiltration of leukaemia (leukaemic MS) and isolated myeloid sarcoma. The incidence of isolated myeloid sarcoma is low. In particular, isolated myeloid sarcoma involving the pancreas is extremely rare and prone to misdiagnosis. This case report describes the long and eventful diagnostic process of a case of myeloid sarcoma involving the pancreas and orbit. Due to a lack of typical clinical manifestations and imaging characteristics, the patient underwent several rounds of treatment without a confirmed diagnosis. Eventually, the final diagnosis was pathologically confirmed using several types of biopsies and immunohistochemical detection. To date, this type of disease has not been reported in the literature. This case report describes the detailed diagnostic process and discusses the strategies used for diagnosis, which will facilitate the diagnosis of such diseases in the future.

Keywords: Granulocytic sarcoma; Immunohistochemistry; Isolated myeloid sarcoma; Orbit; Pancreas.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Abdominal computed tomography scan. A. Axial projection shows the pancreatic duct, intrahepatic, and extrahepatic bile duct dilation (white arrow heads) and low-density pancreatic mass (black arrow head); B. Axial arterial phase projection showing intrahepatic bile duct dilatation and pneumobilia (white arrow head) and pancreatic mass enlargement and enhancement (black arrow head); C. Axial portal phase projection showing portal cavernous transformation (white arrow head) and partial enhancement of the pancreatic mass and areas of low density in the center.
Figure 2
Figure 2
Haematoxylin and eosin stainin (magnification × 400) shows heterotypic cells arranged in a line that appear flaky and demonstrate infiltrative growth (A), the inserts show CD43, Ki-67, and MPO expression.
Figure 3
Figure 3
The results of T1-weighted (A) and T2-weighted (B) magnetic resonance imaging scans of the orbit show a uniform signal-intensity mass in the right lateral rectus area and right optic nerve compression with displacement.
See this image and copyright information in PMC

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