Classification of inhibitory amino acid receptors in the mammalian nervous system
- PMID: 3029518
Classification of inhibitory amino acid receptors in the mammalian nervous system
Abstract
Electrophysiological and pharmacological evidence is summarized for the existence of an inhibitory receptor system operated by glycine and another two separate systems operated by gamma-aminobutyric acid (GABA) through GABA-A and GABA-B receptors, respectively. Claims for subclasses of GABA-A receptor are critically reviewed and found not-proven. A quantitative pharmacological profile of the GABA-A receptor and associated regulatory sites for picrotoxin, barbiturates and benzodiazepines on the dorsal funiculus of the rat cuneate nucleus is described. When compared with this profile and the pharmacological properties of the glycine receptor complex, the effects of taurine cannot be entirely explained by actions on these two receptor systems.
Similar articles
-
Distinction between the effects of barbiturates, benzodiazepines and phenytoin on responses to gamma-aminobutyric acid receptor activation and antagonism by bicuculline and picrotoxin.Br J Pharmacol. 1981 Jul;73(3):739-47. doi: 10.1111/j.1476-5381.1981.tb16810.x. Br J Pharmacol. 1981. PMID: 6265019 Free PMC article.
-
A site for the potentiation of GABA-mediated responses by benzodiazepines.Nature. 1980 Apr 10;284(5756):558-60. doi: 10.1038/284558a0. Nature. 1980. PMID: 6245368
-
Taurine activates glycine and gamma-aminobutyric acid A receptors in rat substantia gelatinosa neurons.Neuroreport. 2008 Feb 12;19(3):333-7. doi: 10.1097/WNR.0b013e3282f50c90. Neuroreport. 2008. PMID: 18303577
-
[Gamma-aminobutyric acid receptors in the central nervous system of mammals].Neirofiziologiia. 1986;18(2):273-82. Neirofiziologiia. 1986. PMID: 3012383 Review. Russian.
-
The complexity of the GABAA receptor shapes unique pharmacological profiles.Drug Discov Today. 2009 Sep;14(17-18):866-75. doi: 10.1016/j.drudis.2009.06.009. Epub 2009 Jul 2. Drug Discov Today. 2009. PMID: 19576998 Review.
Cited by
-
An electrophysiological investigation of the characteristics and function of GABAA receptors on bovine adrenomedullary chromaffin cells.Pflugers Arch. 1989 Oct;415(1):95-103. doi: 10.1007/BF00373146. Pflugers Arch. 1989. PMID: 2560166
-
Taurine infused intrastriatally elevates, but intranigrally decreases striatal extracellular dopamine concentration in anaesthetised rats.J Neural Transm (Vienna). 1996;103(8-9):935-46. doi: 10.1007/BF01291784. J Neural Transm (Vienna). 1996. PMID: 9013387
-
Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors.Neuropharmacology. 2015 Jun;93:28-40. doi: 10.1016/j.neuropharm.2015.01.001. Epub 2015 Jan 26. Neuropharmacology. 2015. PMID: 25634239 Free PMC article.
-
On the histamine-induced depolarization of the isolated superior cervical ganglion of the rat.Br J Pharmacol. 1991 Jul;103(3):1752-6. doi: 10.1111/j.1476-5381.1991.tb09858.x. Br J Pharmacol. 1991. PMID: 1933137 Free PMC article.
-
Effects of taurine, homotaurine and GABA on hypothalamic and striatal dopamine metabolism.Naunyn Schmiedebergs Arch Pharmacol. 1992 Jul;346(1):57-62. doi: 10.1007/BF00167571. Naunyn Schmiedebergs Arch Pharmacol. 1992. PMID: 1407006