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. 2019 May 15;35(10):1763-1765.
doi: 10.1093/bioinformatics/bty851.

VIRULIGN: fast codon-correct alignment and annotation of viral genomes

Affiliations

VIRULIGN: fast codon-correct alignment and annotation of viral genomes

Pieter J K Libin et al. Bioinformatics. .

Abstract

Summary: Virus sequence data are an essential resource for reconstructing spatiotemporal dynamics of viral spread as well as to inform treatment and prevention strategies. However, the potential benefit of these applications critically depends on accurate and correctly annotated alignments of genetically heterogeneous data. VIRULIGN was built for fast codon-correct alignments of large datasets, with standardized and formalized genome annotation and various alignment export formats.

Availability and implementation: VIRULIGN is freely available at https://github.com/rega-cev/virulign as an open source software project.

Supplementary information: Supplementary data is available at Bioinformatics online.

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References

    1. Abascal F. et al. (2010) TranslatorX: multiple alignment of nucleotide sequences guided by amino acid translations. Nucleic Acids Res., 38(Suppl 2), W7–W13. - PMC - PubMed
    1. Dellicour S. et al. (2018) Phylodynamic assessment of intervention strategies for the West African Ebola virus outbreak. Nat. Commun., 9, 2222. - PMC - PubMed
    1. Edgar R.C. (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res., 32, 1792–1797. - PMC - PubMed
    1. Hadfield J. et al. (2018) Nextstrain: real-time tracking of pathogen evolution. Bioinformatics, 34, 4121–4123. - PMC - PubMed
    1. Houldcroft C.J. et al. (2017) Clinical and biological insights from viral genome sequencing. Nat. Rev. Microbiol., 15, 183–192. - PMC - PubMed

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