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. 2019;53(3):284-295.
doi: 10.1159/000493031. Epub 2018 Oct 8.

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

Nebu Philip  1
Affiliations

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

Nebu Philip. Caries Res. 2019.

Abstract

The principles of minimally invasive dentistry clearly dictate the need for clinically effective measures to remineralize early enamel caries lesions. While fluoride-mediated remineralization is the cornerstone of current caries management philosophies, a number of new remineralization strategies have been commercialized or are under development that claim to promote deeper remineralization of lesions, reduce the potential risks associated with high-fluoride oral care products, and facilitate caries control over a lifetime. These non-fluoride remineralizing systems can be broadly categorized into biomimetic enamel regenerative technologies and the approaches that repair caries lesions by enhancing fluoride efficacy. This paper discusses the rationale for non-fluoride remineralization and the mechanism of action, challenges, and evidence behind some of the most promising advances in enamel remineralization therapies.

Keywords: Enamel caries; Fluoride booster; Non-fluoride remineralization; Remineralization.

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References

    1. Agustsdottir H, Gudmundsdottir H, Eggertsson H, Jonsson SH, Gudlaugsson JO, Saemundsson SR, Eliasson ST, Arnadottir IB, Holbrook WP. Caries prevalence of permanent teeth: a national survey of children in Iceland using ICDAS. Community Dent Oral Epidemiol. 2010;38:299–309. - PubMed
    1. AIHW: Dental and Oral Health Overview Australian Welfare 2017. Australian Welfare Series No13. AUS 214. Canberra, AIHW. 2018
    1. Alkilzy M, Santamaria RM, Schmoeckel J, Splieth CH. Treatment of carious lesions using self-assembling peptides. Adv Dent Res. 2018a;29:42–47. - PubMed
    1. Alkilzy M, Tarabaih A, Santamaria RM, Splieth CH. Self-assembling peptide P11-4 and fluoride for regenerating enamel. J Dent Res. 2018b;97:148–154. - PMC - PubMed
    1. Alkilzy M, Tarabaih A, Splieth CH. Efficacy, clinical applicability and safety of CurodontTM Repair in children with early occlusal caries. Caries Res. 2015;49:311.