Tumors evading CARs-the chase is on

Sarwish Rafiq^{1

2}, Renier J Brentjens^{3

4

5}

Affiliations

¹ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. brentjer@mskcc.org.
⁴ Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA. brentjer@mskcc.org.
⁵ Department of Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. brentjer@mskcc.org.

Comment

Sarwish Rafiq et al. Nat Med. 2018 Oct.

. 2018 Oct;24(10):1492-1493.

doi: 10.1038/s41591-018-0212-6.

Sarwish Rafiq^{1

2}, Renier J Brentjens^{3

4

5}

¹ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. brentjer@mskcc.org.
⁴ Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA. brentjer@mskcc.org.
⁵ Department of Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. brentjer@mskcc.org.

No abstract available

Comment on

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell.
Ruella M, Xu J, Barrett DM, Fraietta JA, Reich TJ, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, Nazimuddin F, Bhoj VG, Orlando EJ, Fry TJ, Bitter H, Maude SL, Levine BL, Nobles CL, Bushman FD, Young RM, Scholler J, Gill SI, June CH, Grupp SA, Lacey SF, Melenhorst JJ. Ruella M, et al. Nat Med. 2018 Oct;24(10):1499-1503. doi: 10.1038/s41591-018-0201-9. Epub 2018 Oct 1. Nat Med. 2018. PMID: 30275568 Free PMC article.
Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia.
Orlando EJ, Han X, Tribouley C, Wood PA, Leary RJ, Riester M, Levine JE, Qayed M, Grupp SA, Boyer M, De Moerloose B, Nemecek ER, Bittencourt H, Hiramatsu H, Buechner J, Davies SM, Verneris MR, Nguyen K, Brogdon JL, Bitter H, Morrissey M, Pierog P, Pantano S, Engelman JA, Winckler W. Orlando EJ, et al. Nat Med. 2018 Oct;24(10):1504-1506. doi: 10.1038/s41591-018-0146-z. Epub 2018 Oct 1. Nat Med. 2018. PMID: 30275569

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