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Review
. 2018 Sep 21:9:1291.
doi: 10.3389/fphys.2018.01291. eCollection 2018.

The Influence of MicroRNAs on Mitochondrial Calcium

Carolina Jaquenod De Giusti  1 , Barbara Roman  2 , Samarjit Das  2
Affiliations
Review

The Influence of MicroRNAs on Mitochondrial Calcium

Carolina Jaquenod De Giusti et al. Front Physiol. .

Abstract

Abnormal mitochondrial calcium ([Ca2+]m) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulate mitochondrial activities, including [Ca2+]m uptake. Apart from this subset of miRNAs, there are several miRNAs that have been reported to target genes that play a role in maintaining [Ca2+]m levels in the cytoplasm. It is imperative to validate miRNAs that alter [Ca2+]m handling, and thereby alter cellular fate. The focus of this review is to highlight the mitochondrial miRNAs (MitomiRs), and other cytosolic miRNAs that target mRNAs which play an important role in [Ca2+]m handling.

Keywords: MitomiR; heart failure; miRNA; microRNA; mitochondria; mitochondrial calcium.

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Figures

Figure 1
Figure 1
Mechanism of Action by which miRNAs regulate Ca2+-intake into the Mitochondria.
See this image and copyright information in PMC

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