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Comment
. 2018 Oct 8;34(4):529-530.
doi: 10.1016/j.ccell.2018.09.006.

Genetic Ancestry May Influence the Evolutionary Trajectory of Cancers

Jason J Pitt  1 , Yonglan Zheng  2 , Olufunmilayo I Olopade  3
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Free article
Comment

Genetic Ancestry May Influence the Evolutionary Trajectory of Cancers

Jason J Pitt et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Yuan et al. compared the somatic alterations harbored by tumors from European and African ancestry individuals. They determined that the latter group has a propensity for aberrations that are consistent with genomic instability, potentially lending insight to the genomic basis of cancer health disparities.

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  • Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers.
    Yuan J, Hu Z, Mahal BA, Zhao SD, Kensler KH, Pi J, Hu X, Zhang Y, Wang Y, Jiang J, Li C, Zhong X, Montone KT, Guan G, Tanyi JL, Fan Y, Xu X, Morgan MA, Long M, Zhang Y, Zhang R, Sood AK, Rebbeck TR, Dang CV, Zhang L. Yuan J, et al. Cancer Cell. 2018 Oct 8;34(4):549-560.e9. doi: 10.1016/j.ccell.2018.08.019. Cancer Cell. 2018. PMID: 30300578 Free PMC article.

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