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Comment
. 2018 Oct 8;34(4):533-535.
doi: 10.1016/j.ccell.2018.09.004.

Intratumoral Heterogeneity: Tools to Understand and Exploit Clone Wars in AML

George Giotopoulos  1 , Brian J P Huntly  2
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Intratumoral Heterogeneity: Tools to Understand and Exploit Clone Wars in AML

George Giotopoulos et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, de Boer et al. refine a set of acute myeloid leukemia (AML)-enriched plasma membrane markers that can be used to identify, prospectively isolate, and longitudinally track leukemic subclones within individual AML patients, correlating immunophenotypic profiles with specific mutational signatures, transcription, functional behavior, and therapeutic outcomes.

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