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. 2018 Oct 5;23(10):2541.
doi: 10.3390/molecules23102541.

Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

Sio-Hong Lam  1 , Po-Hsun Chen  2 , Hsin-Yi Hung  3 , Tsong-Long Hwang  4   5   6 , Chih-Chao Chiang  7   8   9 , Tran Dinh Thang  10   11 , Ping-Chung Kuo  12 , Tian-Shung Wu  13   14
Affiliations

Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

Sio-Hong Lam et al. Molecules. .

Abstract

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

Keywords: Menispermaceae; elastase release.; lignan; pyrrole alkaloid; superoxide anion generation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1 and 11–17.
Figure 2
Figure 2
Diagnostic HMBC (→) and NOESY (↔) correlations of compound 1.
Figure 3
Figure 3
Diagnostic HMBC (→)/COSY (---) correlations of compounds 11 and 12.
Figure 4
Figure 4
Diagnostic HMBC (→) correlations of compound 16.
See this image and copyright information in PMC

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