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Review
. 2018 Sep 13:2018:1963024.
doi: 10.1155/2018/1963024. eCollection 2018.

Metabolic Engineered Biocatalyst: A Solution for PLA Based Problems

Sundus Riaz  1   2 , Nosheen Fatima  1 , Ahmed Rasheed  3 , Mehvish Riaz  4 , Faiza Anwar  2 , Yamna Khatoon  5
Affiliations
Review

Metabolic Engineered Biocatalyst: A Solution for PLA Based Problems

Sundus Riaz et al. Int J Biomater. .

Abstract

Polylactic acid (PLA) is a biodegradable thermoplastic polyester. In 2010, PLA became the second highest consumed bioplastic in the world due to its wide application. Conventionally, PLA is produced by direct condensation of lactic acid monomer and ring opening polymerization of lactide, resulting in lower molecular weight and lesser strength of polymer. Furthermore, conventional methods of PLA production require a catalyst which makes it inappropriate for biomedical applications. Newer method utilizes metabolic engineering of microorganism for direct production of PLA through fermentation which produces good quality and high molecular weight and yield as compared to conventional methods. PLA is used as decomposing packaging material, sheet casting, medical implants in the form of screw, plate, and rod pin, etc. The main focus of the review is to highlight the synthesis of PLA by various polymerization methods that mainly include metabolic engineering fermentation as well as salient biomedical applications of PLA.

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Figures

Figure 1
Figure 1
Methods of production of lactic acid.
Figure 2
Figure 2
A schematic presentation of production of Lactic Acid by chemical process.
Figure 3
Figure 3
A schematic presentation of steps involved in production and purification of lactic acid by fermentation.
Figure 4
Figure 4
A schematic presentation of recovery and purification of lactic acid from fermentation of broth by adsorption.
Figure 5
Figure 5
A schematic presentation of production of polylactic acid by metabolic engineering.
See this image and copyright information in PMC

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