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. 1987;93(3-4):233-45.
doi: 10.1007/BF01310977.

Serologic differences among nondefective reticuloendotheliosis viruses

Serologic differences among nondefective reticuloendotheliosis viruses

P Y Chen et al. Arch Virol. 1987.

Erratum in

  • Arch Virol 1987;95(1-2):157

Abstract

Antigenic relationships among 26 isolates of reticuloendotheliosis virus (REV) obtained from several avian species were compared by cross neutralization tests with polyclonal chicken sera and by immunofluorescent assays with monoclonal antibodies to REV strain T. The isolates were all strongly related by neutralization assays and thus probably constitute a single serotype. However, 3 antigenic subtypes were suggested by minor but distinct differences in neutralization titers. The validity of these 3 subtype designations was confirmed by differential reactivity of viral isolates to selected monoclonal antibodies. Subtype-associated differences in serum antibody titers were noted following the inoculation of chickens with the REV isolates.

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