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. 2018 Nov 10;218(suppl_4):S222-S226.
doi: 10.1093/infdis/jiy543.

Case-Fatality Ratio of Blood Culture-Confirmed Typhoid Fever in Dhaka, Bangladesh

Alexander T Yu  1 , Nuhu Amin  2 , Muhammad Waliur Rahman  2 , Emily S Gurley  2   3 , Kazi Mizanur Rahman  4 , Stephen P Luby  1
Affiliations

Case-Fatality Ratio of Blood Culture-Confirmed Typhoid Fever in Dhaka, Bangladesh

Alexander T Yu et al. J Infect Dis. .

Abstract

With impending rollout of new conjugate typhoid vaccines, better estimates of typhoid case-fatality ratio are needed for countries to set priorities for public health programs. We enrolled 1425 patients of all ages with blood culture-confirmed Salmonella Typhi from laboratory networks serving inpatients and outpatients in Dhaka, Bangladesh. Participants were asked about symptoms and complications including death experienced over a median 3-month period following blood culture diagnosis. Four fatal cases were identified (case-fatality ratio of 0.3% [95% confidence interval, .05%-.55%]). Applying this case-fatality ratio to global typhoid burden estimates would reduce deaths by 70%.

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