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Review
. 2018 Oct 9;19(10):3082.
doi: 10.3390/ijms19103082.

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

Hao Chi  1 , Hui-Yun Chang  2 , Tzu-Kang Sang  3
Affiliations
Review

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

Hao Chi et al. Int J Mol Sci. .

Abstract

Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, neuronal cell death is restricted in the adult brain, even in aged individuals. However, in the pathological conditions of various neurodegenerative diseases, cell death and shrinkage in a specific region of the brain represent a fundamental pathological feature across different neurodegenerative diseases. In this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common neurodegenerative diseases, discussing our current understanding of cell death by connecting with renowned pathogenic proteins, including Tau, amyloid-beta, alpha-synuclein, huntingtin and TDP-43.

Keywords: apoptosis; necroptosis; neurodegeneration.

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Conflict of interest statement

The authors declare no conflicts of interest.

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