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. 1987 Feb 10;403(1):96-104.
doi: 10.1016/0006-8993(87)90127-2.

The effect of hypophysectomy, ACTH fragments and thalamic lesions upon kindled epilepsy

O L Rogers 3rd, W J Jackson

The effect of hypophysectomy, ACTH fragments and thalamic lesions upon kindled epilepsy

O L Rogers 3rd et al. Brain Res. .

Abstract

Hypophysectomized rats showed aberrant and retarded rates of kindled epilepsy. In hypophysectomized rats administered adrenocorticotropic hormone (ACTH) subunits ACTH4-10 and ACTH1-24, the normal kindling pattern was restored. However, in hypophysectomized animals which also had lesions of the thalamus (nucleus parafascicularis), ACTH4-10 did not restore the normal pattern of kindling. There have been many conjectures that kindling may be a subcase of learning. These results are compatible with this hypothesis, since the same procedures act in an analogous fashion within avoidance conditioning paradigms.

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