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Observational Study
. 2018 Oct 11;19(1):259.
doi: 10.1186/s12882-018-1055-6.

High rates of central obesity and sarcopenia in CKD irrespective of renal replacement therapy - an observational cross-sectional study

Jutta Dierkes  1 , Helene Dahl  2 , Natasha Lervaag Welland  2 , Kristina Sandnes  2 , Kristin Sæle  3 , Ingegjerd Sekse  3 , Hans-Peter Marti  2   3
Affiliations
Observational Study

High rates of central obesity and sarcopenia in CKD irrespective of renal replacement therapy - an observational cross-sectional study

Jutta Dierkes et al. BMC Nephrol. .

Erratum in

Abstract

Background: Poor nutritional status of patients with renal disease has been associated with worsening of renal function and poor health outcomes. Simply measuring weight and height for calculation of the body mass index does however not capture the true picture of nutritional status in these patients. Therefore, we measured nutritional status by BMI, body composition, waist circumference, dietary intake and nutritional screening in three groups of renal patients.

Methods: Patients with chronic kidney disease not on renal replacement therapy (CKD stages 3-5, n = 112), after renal transplantation (n = 72) and patients treated with hemodialysis (n = 24) were recruited in a tertiary hospital in Bergen, Norway in a cross-sectional observational study. Dietary intake was assessed by a single 24 h recall. All patients underwent nutritional screening, anthropometric measurements, body composition measurement andfunctional measurements (hand grip strength). The prevalence of overweight and obesity, central obesity, sarcopenia, sarcopenic obesity and nutritional risk was calculated.

Results: Central obesity and sarcopenia were present in 49% and 35% of patients, respectively. 49% of patients with central obesity were normal weight or overweight according to their BMI. Factors associated with central obesity were a diagnosis of diabetes and increased fat mass, while factors associated with sarcopenia were age, female gender, number of medications. An increase in the BMI was associated with lower risk for sarcopenia.

Conclusion: Central obesity and sarcopenia were present in renal patients at all disease stages. More attention to these unfavorable nutritional states is warranted in these patients.

Keywords: ESRD; Nutritional status; Renal disease; Sarcopenia.

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Conflict of interest statement

Ethics approval and consent to participate

The study was conducted in accordance with principles of the Declaration of Helsinki and was approved by the Regional Committee for Medical and Health Research Ethics (REK Vest, (regionale komiteer for medisinik og helsefaglig forskningsetikk, University of Bergen, No. 2014/1790). All patients signed an informed consent prior to participation.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests. The results presented in this paper have not been published elsewhere in whole or in part, except in abstract form.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Nutritional status of patients according to stage of kidney disease (CKD chronic kidney disease; ESRD-HD end-stage renal disease treated with hemodialysis; Tx: recipients of a renal transplant) and established BMI cut-offs (a) and according to sarcopenia, central obesity and sarcopenic obesity (b). Sarcopenia was defined by low skeletal muscle index and low hand grip strength, central obesity according to waist circumference and sarcopenic obesity as presence of sarcopenia and central obesity
See this image and copyright information in PMC

References

    1. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260–272. doi: 10.1016/S0140-6736(13)60687-X. - DOI - PubMed
    1. Nazar CM. Significance of diet in chronic kidney disease. J Nephropharmacol. 2013;2:37–43. - PMC - PubMed
    1. Cao X, Zhou J, Yuan H, Wu L, Chen Z. Chronic kidney disease among overweight and obesity with and without metabolic syndrome in an urban Chinese cohort. BMC Nephrol. 2015;16:85. doi: 10.1186/s12882-015-0083-8. - DOI - PMC - PubMed
    1. Feller S, Boeing H, Pischon T. Body mass index, waist circumference, and the risk of type 2 diabetes mellitus : implications for routine clinical practice. Dtsch Arztebl Int. 2010;107:470–476. - PMC - PubMed
    1. Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med. 2008;359:2105–2120. doi: 10.1056/NEJMoa0801891. - DOI - PubMed

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