Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Oct 11;22(1):258.
doi: 10.1186/s13054-018-2191-x.

Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

Jing Li  1
Affiliations
Comment

Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

Jing Li. Crit Care. .

Abstract

Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary extends both reviews by integrating a meta-analysis and sharing aggregated results. Pooled analyses demonstrated a marked reduction in mortality and duration of vasopressor administration in the group with the use of vitamin C.

Keywords: Ascorbic acid; Meta-analysis; Sepsis; Sepsis management; Severe sepsis; Vitamin C.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The author declares that she has no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Pooled analyses of mortality (a), ICU-LOS in days (b), and vasopressor duration in hours (c). ICU-LOS intensive care unit length of stay, CI confidence interval
See this image and copyright information in PMC

Comment on

References

    1. Sheikh M, Horner D. Bet 2: does intravenous vitamin C improve mortality in patients with severe sepsis? Emerg Med J. 2018;35(4):272–274. doi: 10.1136/emermed-2018-207608.3. - DOI - PubMed
    1. Teng J, Pourmand A, Mazer-Amirshahi M. Vitamin C: the next step in sepsis management? J Crit Care. 2018;43:230–234. doi: 10.1016/j.jcrc.2017.09.031. - DOI - PubMed
    1. Fowler AA, 3rd, Syed AA, Knowlson S, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med. 2014;12:32. doi: 10.1186/1479-5876-12-32. - DOI - PMC - PubMed
    1. Natarajan R, Fisher BJ, Syed AA, et al. Impact of intravenous ascorbic acid infusion on novel biomarkers in patients with severe sepsis. J Pulm Respir Med. 2014;4(6):2. doi: 10.4172/2161-105X.1000214. - DOI
    1. Tanaka H, Matsuda T, Miyagantani Y, et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch Surg. 2000;135(3):326–331. doi: 10.1001/archsurg.135.3.326. - DOI - PubMed