Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Oct 3:18:152.
doi: 10.1186/s12935-018-0647-3. eCollection 2018.

Prognostic value of microvessel density in cervical cancer

Xiaoli Hu  1 , Hailing Liu  1 , Miaomiao Ye  1 , Xueqiong Zhu  1
Affiliations
Review

Prognostic value of microvessel density in cervical cancer

Xiaoli Hu et al. Cancer Cell Int. .

Abstract

Background: Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefore, we performed a meta-analysis to evaluate the association between microvessel density and the survival probability of patients with cervical cancer.

Method: There was a comprehensive search of the PubMed, EMBASE and Cochrane databases up to August 31, 2017. Based on a fixed-effects or random-effects model, the hazard ratio (HR) and 95% confidence intervals (CIs) were calculated from researches on overall survival (OS) and disease-free survival (DFS).

Result: Totally, we included 13 observational researches, involving 1097 patients with cervical cancer. The results showed that high level of microvessel density was negatively correlated with OS (HR = 1.79, 95% CIs 1.31-2.44, I 2 = 60.7%, P = 0.003) and DFS (HR = 1.47, 95% CIs 1.13-1.80, I 2 = 0%, P = 0.423) of cervical cancer patients. In subgroup analysis, high counts of MVD were significantly associated with a poor survival (including OS and DFS) of the patients detected by anti-factor VIII antibodies or in European origin.

Conclusion: The present meta-analysis indicated that survival with high level of MVD was significant poorer than with low MVD in cervical cancer patient. Standardization of MVD assessment is needed.

Keywords: Cervical neoplasia; Meta-analysis; Microvessel density; Survival.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow diagram for study selection
Fig. 2
Fig. 2
The forest plot assesses the association between MVD and cervical cancer with OS
Fig. 3
Fig. 3
Subgroup analysis of association between count of MVD and prognosis of cervical cancer with OS detected by different antibodies
Fig. 4
Fig. 4
Subgroup analysis of association between count of MVD and prognosis of cervical cancer with OS in different populations
Fig. 5
Fig. 5
The forest plot illustrates the association between MVD and DFS of cervical cancer
Fig. 6
Fig. 6
Subgroup analysis of association between count of MVD and prognosis of cervical cancer with DFS detected by different antibodies
Fig. 7
Fig. 7
Subgroup analysis of association between count of MVD and prognosis of cervical cancer with DFS in different populations
Fig. 8
Fig. 8
Sensitivity analysis to assess the stability of the pooled outcomes between count of MVD and prognosis of cervical cancer. a OS; b DFS
Fig. 9
Fig. 9
The presence of publication bias for the overall relationship between MVD level and the prognosis of cervical cancer. a OS; b DFS
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. doi: 10.3322/caac.21442. - DOI - PubMed
    1. Kress CM, Sharling L, Owen-Smith AA, Desalegn D, Blumberg HM, Goedken J. Knowledge, attitudes, and practices regarding cervical cancer and screening among Ethiopian health care workers. Int J Womens Health. 2015;7:765–772. - PMC - PubMed
    1. Intaraphet S, Kasatpibal N, Siriaunkgul S, Sogaard M, Patumanond J, Khunamornpong S, Chandacham A, Suprasert P. Prognostic impact of histology in patients with cervical squamous cell carcinoma, adenocarcinoma and small cell neuroendocrine carcinoma. Asian Pac J Cancer Prev. 2013;14(9):5355–5360. doi: 10.7314/APJCP.2013.14.9.5355. - DOI - PubMed
    1. Horn LC, Bilek K, Fischer U, Einenkel J, Hentschel B. A cut-off value of 2 cm in tumor size is of prognostic value in surgically treated FIGO stage IB cervical cancer. Gynecol Oncol. 2014;134(1):42–46. doi: 10.1016/j.ygyno.2014.04.011. - DOI - PubMed
    1. Leek RD. The prognostic role of angiogenesis in breast cancer. Anticancer Res. 2001;21(6B):4325–4331. - PubMed

LinkOut - more resources