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Review
. 2018 Oct 3:18:152.
doi: 10.1186/s12935-018-0647-3. eCollection 2018.

Prognostic value of microvessel density in cervical cancer

Xiaoli Hu  1 , Hailing Liu  1 , Miaomiao Ye  1 , Xueqiong Zhu  1
Affiliations
Review

Prognostic value of microvessel density in cervical cancer

Xiaoli Hu et al. Cancer Cell Int. .

Abstract

Background: Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefore, we performed a meta-analysis to evaluate the association between microvessel density and the survival probability of patients with cervical cancer.

Method: There was a comprehensive search of the PubMed, EMBASE and Cochrane databases up to August 31, 2017. Based on a fixed-effects or random-effects model, the hazard ratio (HR) and 95% confidence intervals (CIs) were calculated from researches on overall survival (OS) and disease-free survival (DFS).

Result: Totally, we included 13 observational researches, involving 1097 patients with cervical cancer. The results showed that high level of microvessel density was negatively correlated with OS (HR = 1.79, 95% CIs 1.31-2.44, I 2 = 60.7%, P = 0.003) and DFS (HR = 1.47, 95% CIs 1.13-1.80, I 2 = 0%, P = 0.423) of cervical cancer patients. In subgroup analysis, high counts of MVD were significantly associated with a poor survival (including OS and DFS) of the patients detected by anti-factor VIII antibodies or in European origin.

Conclusion: The present meta-analysis indicated that survival with high level of MVD was significant poorer than with low MVD in cervical cancer patient. Standardization of MVD assessment is needed.

Keywords: Cervical neoplasia; Meta-analysis; Microvessel density; Survival.

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Figures

Fig. 1
Fig. 1
Flow diagram for study selection
Fig. 2
Fig. 2
The forest plot assesses the association between MVD and cervical cancer with OS
Fig. 3
Fig. 3
Subgroup analysis of association between count of MVD and prognosis of cervical cancer with OS detected by different antibodies
Fig. 4
Fig. 4
Subgroup analysis of association between count of MVD and prognosis of cervical cancer with OS in different populations
Fig. 5
Fig. 5
The forest plot illustrates the association between MVD and DFS of cervical cancer
Fig. 6
Fig. 6
Subgroup analysis of association between count of MVD and prognosis of cervical cancer with DFS detected by different antibodies
Fig. 7
Fig. 7
Subgroup analysis of association between count of MVD and prognosis of cervical cancer with DFS in different populations
Fig. 8
Fig. 8
Sensitivity analysis to assess the stability of the pooled outcomes between count of MVD and prognosis of cervical cancer. a OS; b DFS
Fig. 9
Fig. 9
The presence of publication bias for the overall relationship between MVD level and the prognosis of cervical cancer. a OS; b DFS
See this image and copyright information in PMC

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