Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria

doi:10.1007/s00394-018-1844-5

Review

. 2019 Aug;58(5):1771-1784.

doi: 10.1007/s00394-018-1844-5. Epub 2018 Oct 10.

Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria

Katherine J P Schwenger^{1

2}, Colin M Bolzon², Carrie Li², Johane P Allard^{3

4

5}

Affiliations

¹ Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
² Toronto General Hospital, University Health Network, 585 University Avenue, 9-973, Toronto, ON, M5G 2C4, Canada.
³ Toronto General Hospital, University Health Network, 585 University Avenue, 9-973, Toronto, ON, M5G 2C4, Canada. Dr.Johane.Allard@uhn.ca.
⁴ Department of Medicine, University of Toronto, Toronto, Canada. Dr.Johane.Allard@uhn.ca.
⁵ Department of Nutritional Sciences, University of Toronto, Toronto, Canada. Dr.Johane.Allard@uhn.ca.

PMID: 30306296
DOI: 10.1007/s00394-018-1844-5

Review

Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria

Katherine J P Schwenger et al. Eur J Nutr. 2019 Aug.

. 2019 Aug;58(5):1771-1784.

doi: 10.1007/s00394-018-1844-5. Epub 2018 Oct 10.

Authors

Katherine J P Schwenger^{1

2}, Colin M Bolzon², Carrie Li², Johane P Allard^{3

4

5}

Affiliations

¹ Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
² Toronto General Hospital, University Health Network, 585 University Avenue, 9-973, Toronto, ON, M5G 2C4, Canada.
³ Toronto General Hospital, University Health Network, 585 University Avenue, 9-973, Toronto, ON, M5G 2C4, Canada. Dr.Johane.Allard@uhn.ca.
⁴ Department of Medicine, University of Toronto, Toronto, Canada. Dr.Johane.Allard@uhn.ca.
⁵ Department of Nutritional Sciences, University of Toronto, Toronto, Canada. Dr.Johane.Allard@uhn.ca.

PMID: 30306296
DOI: 10.1007/s00394-018-1844-5

Abstract

Non-alcoholic fatty-liver disease (NAFLD) is now considered one of the leading causes of liver disease worldwide and is associated with metabolic syndrome and obesity. There are several factors contributing to the disease state. Recent research suggests that the intestinal microbiota (IM) and bacterial products may play a role through several mechanisms which include increased energy uptake, intestinal permeability and chronic inflammation. In addition to diet and exercise, treatment options targeting the IM are being investigated and include the use of pre-, pro- and synbiotics as well as the possibility of fecal microbial transfers. This literature review explores the relationship between NAFLD and the IM as well as highlight new IM treatment options that may become available in the near future.

Keywords: Fecal transplant; Gut bacteria; Non-alcoholic fatty liver disease; Obesity; Prebiotics.

PubMed Disclaimer

Cited by

Association between Inflammatory Biomarkers and Nutritional Status in Fatty Liver.
Lim HS, Choi J, Lee B, Kim SG, Kim YS, Yoo JJ. Lim HS, et al. Clin Nutr Res. 2020 Jul 28;9(3):182-194. doi: 10.7762/cnr.2020.9.3.182. eCollection 2020 Jul. Clin Nutr Res. 2020. PMID: 32789148 Free PMC article.
Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice.
Hong Y, Sheng L, Zhong J, Tao X, Zhu W, Ma J, Yan J, Zhao A, Zheng X, Wu G, Li B, Han B, Ding K, Zheng N, Jia W, Li H. Hong Y, et al. Gut Microbes. 2021 Jan-Dec;13(1):1-20. doi: 10.1080/19490976.2021.1930874. Gut Microbes. 2021. PMID: 34125646 Free PMC article.
Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease.
Rico D, Martin-Diana AB, Lasa A, Aguirre L, Milton-Laskibar I, de Luis DA, Miranda J. Rico D, et al. Nutrients. 2019 Jan 4;11(1):86. doi: 10.3390/nu11010086. Nutrients. 2019. PMID: 30621142 Free PMC article.
Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal-Regulating Kinase 1 Pathways.
Huang Z, Wu LM, Zhang JL, Sabri A, Wang SJ, Qin GJ, Guo CQ, Wen HT, Du BB, Zhang DH, Kong LY, Tian XY, Yao R, Li YP, Liang C, Li PC, Wang Z, Guo JY, Li L, Dong JZ, Zhang YZ. Huang Z, et al. Hepatology. 2019 Oct;70(4):1099-1118. doi: 10.1002/hep.30597. Epub 2019 Apr 22. Hepatology. 2019. PMID: 30820969 Free PMC article.
Impact of urbanization on gut microbiome mosaics across geographic and dietary contexts.
Vinogradova E, Mukhanbetzhanov N, Nurgaziyev M, Jarmukhanov Z, Aipova R, Sailybayeva A, Bekbossynova M, Kozhakhmetov S, Kushugulova A. Vinogradova E, et al. mSystems. 2024 Oct 22;9(10):e0058524. doi: 10.1128/msystems.00585-24. Epub 2024 Sep 17. mSystems. 2024. PMID: 39287374 Free PMC article.

See all "Cited by" articles

References

1. Gastroenterology. 1999 Jun;116(6):1413-9 - PubMed
1. J Endotoxin Res. 2000;6(6):453-7 - PubMed
1. Hepatology. 2001 Dec;34(6):1158-63 - PubMed
1. Trends Endocrinol Metab. 2002 Mar;13(2):84-9 - PubMed
1. Mol Cell. 2002 Aug;10(2):417-26 - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

[1] Gastroenterology. 1999 Jun;116(6):1413-9 - PubMed

[2] Gastroenterology. 1999 Jun;116(6):1413-9 - PubMed

[3] J Endotoxin Res. 2000;6(6):453-7 - PubMed

[4] J Endotoxin Res. 2000;6(6):453-7 - PubMed

[5] Hepatology. 2001 Dec;34(6):1158-63 - PubMed

[6] Hepatology. 2001 Dec;34(6):1158-63 - PubMed

[7] Trends Endocrinol Metab. 2002 Mar;13(2):84-9 - PubMed

[8] Trends Endocrinol Metab. 2002 Mar;13(2):84-9 - PubMed

[9] Mol Cell. 2002 Aug;10(2):417-26 - PubMed

[10] Mol Cell. 2002 Aug;10(2):417-26 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria

Affiliations

Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Medical