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Comparative Study
. 1987 Jan;6(1):127-31.
doi: 10.3109/02713688709020079.

A critical role for ACAID in the distinctive pattern of retinitis that follows anterior chamber inoculation of HSV-1

Comparative Study

A critical role for ACAID in the distinctive pattern of retinitis that follows anterior chamber inoculation of HSV-1

J W Streilein et al. Curr Eye Res. 1987 Jan.

Abstract

To test the hypothesis that ACAID induction is instrumental in producing the distinctive pattern of retinal pathology that follows anterior chamber inoculation of HSV-1 in BALB/c mice, panels of mice received uniocular anterior chamber, uniocular intravitreal, and bilateral anterior chamber inoculations of HSV-1. It was found that contralateral retinitis developed after the first two routes, and ACAID was induced by all three. Enucleation of eyes inoculated with HSV-1 before 3 days post-inoculation (but not thereafter) prevented both ACAID and contralateral retinitis. Intracameral inoculations of HSV-2 induced vigorous delayed hypersensitivity and failed to incite contralateral retinitis. It is concluded that ACAID induction plays a crucial role in the pathogenesis of contralateral retinitis following anterior chamber inoculation of HSV-1.

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