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Meta-Analysis
. 2019 Jan;40(1):25-39.
doi: 10.1007/s10072-018-3598-5. Epub 2018 Oct 10.

Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache

Alina Buture  1   2 , Fayyaz Ahmed  3   4 , Lisa Dikomitis  5 , Jason W Boland  4   6
Affiliations
Meta-Analysis

Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache

Alina Buture et al. Neurol Sci. 2019 Jan.

Abstract

Introduction: Patients with cluster headache (CH), the most common trigeminal autonomic cephalalgia, often face delayed diagnosis, misdiagnosis and mismanagement.

Objectives: To identify, appraise and synthesise clinical studies on the delays in diagnosis and misdiagnosis of CH in order to determine its causes and help the management of this condition.

Methods: The systematic review was prepared, conducted and reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis. It was registered with International Prospective Register of Systematic Reviews. A systematic search of different electronic databases (Medline, EMBASE, PsycINFO, PubMed, CINAHL, BNI, HMIC, AMED, HBE and Cochrane Library) was carried out in May 2017. Reference lists of relevant articles were hand searched.

Results: The search identified 201 unique studies. Fifteen studies met the inclusion criteria of which 13 case series studies and two survey studies. Nine studies assessed the delays in diagnosis and misdiagnosis of CH, five studies the delays in diagnosis and one study the misdiagnosis of CH. The studies included 4661 patients. Delays in diagnosis, misdiagnosis and mismanagement have been reported in many European countries, Japan and in the USA with well-developed health services. The patients with CH often visited many different clinicians, surgeons and dentists and received multiple diagnosis prior to being correctly diagnosed.

Conclusion: This systematic review shows that the delays in the diagnosis of CH are a widespread problem, the time to diagnosis still vary from country to country and both patients and physicians are responsible for the delays in diagnosis.

Keywords: Diagnostic error; Diagnostic mistake; Mismanagement; Therapeutic error; Unrecognised diagnosis.

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Conflict of interest statement

Ethics approval and consent to participate

Not applicable

Consent for publication

All authors have read and approved the manuscript for publication.

Competing interests

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram of study selection based on Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols
See this image and copyright information in PMC

References

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