Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Dec;34(6):1131-1136.
doi: 10.1007/s12264-018-0294-7. Epub 2018 Oct 10.

The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia

Zhaofei Dong  1 , Kuang Pan  1 , Jingrui Pan  1 , Qingxia Peng  1 , Yidong Wang  2   3   4
Affiliations
Review

The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia

Zhaofei Dong et al. Neurosci Bull. 2018 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors claim no conflicts of interest.

Figures

Fig. 1
Fig. 1
Pyroptosis pathways. In the canonical inflammasome pathway, microbial pathogens (PAMPs) or sterile inflammatory substances (DAMPs) are detected by various cytosolic sensor proteins (PRRs) which leads to caspase-1 activation through an inflammasome complex. Active caspase-1 converts the precursors of IL-1β and IL-18 to their mature forms, which are released from cells by pyroptosis. In the non-canonical pathway, LPS in the cytosol of cells infected by bacteria binds to precursor caspase-4/5/11, which leads to the activation of caspase-4/5/11. Both caspase-1 and caspase-4/5/11 process GSDMD, which results in the release of the N-terminal fragment of GSDMD (GSDMD-N). GSDMD-N forms pores in the plasma membrane that induce pyroptosis. The other pathway of pyroptosis is caspase-3/GSDME (DFNA5). Caspase-3 can be activated by the mitochondrial pathway and the death receptor pathway. Activated caspase-3 in turn cleaves GSDME to generate the GSDME-N fragment that forms pores in the plasma membrane and induces secondary necrosis/pyroptosis [1]. PAMPs pathogen-associated molecular patterns; DAMPs danger-associated molecular patterns; PRRs pattern recognition receptors; ASC apoptosis-associated speck-like protein containing a CARD; LPS lipopolysaccharide; GSDMD gasdermin D; GSDME (DFNA5), gasdermin E (deafness autosomal dominant type 5).
See this image and copyright information in PMC

References

    1. Wang W, Jiang B, Sun H, Ru X, Sun D, Wang L, et al. Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults. Circulation. 2017;135:759–771. doi: 10.1161/CIRCULATIONAHA.116.025250. - DOI - PubMed
    1. Koton S, Schneider AL, Rosamond WD, Shahar E, Sang Y, Gottesman RF, et al. Stroke incidence and mortality trends in US communities, 1987 to 2011. JAMA. 2014;312:259–268. doi: 10.1001/jama.2014.7692. - DOI - PubMed
    1. Norrving B, Kissela B. The global burden of stroke and need for a continuum of care. Neurology. 2013;80:S5–S12. doi: 10.1212/WNL.0b013e3182762397. - DOI - PMC - PubMed
    1. Demaerschalk BM, Kleindorfer DO, Adeoye OM, Demchuk AM, Fugate JE, Grotta JC, et al. Scientific rationale for the inclusion and exclusion criteria for intravenous alteplase in acute ischemic stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016;47:581–641. doi: 10.1161/STR.0000000000000086. - DOI - PubMed
    1. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2018;49:e46–e110. doi: 10.1161/STR.0000000000000158. - DOI - PubMed

MeSH terms

LinkOut - more resources