Topology of gap junction protein and channel function

Abstract

This paper presents recent results from this laboratory concerning the topological structure and function of the major 27 kDa gap junction protein. Immunological, biochemical and biophysical observations now provide evidence for the localization of the 27 kDa protein to gap junction structures, both in vivo and in vitro, and for the participation of the 27 kDa protein in channel conductance.