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. 2018 Oct 11;36(34):JCO1801097.
doi: 10.1200/JCO.18.01097. Online ahead of print.

Hypofractionated Radiation Therapy for Localized Prostate Cancer: An ASTRO, ASCO, and AUA Evidence-Based Guideline

Scott C Morgan  1 , Karen Hoffman  1 , D Andrew Loblaw  1 , Mark K Buyyounouski  1 , Caroline Patton  1 , Daniel Barocas  1 , Soren Bentzen  1 , Michael Chang  1 , Jason Efstathiou  1 , Patrick Greany  1 , Per Halvorsen  1 , Bridget F Koontz  1 , Colleen Lawton  1 , C Marc Leyrer  1 , Daniel Lin  1 , Michael Ray  1 , Howard Sandler  1
Affiliations

Hypofractionated Radiation Therapy for Localized Prostate Cancer: An ASTRO, ASCO, and AUA Evidence-Based Guideline

Scott C Morgan et al. J Clin Oncol. .
No abstract available

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Figures

Fig 1.
Fig 1.
(A) Rectal dose constraints from trials of moderate hypofractionation. (B) Bladder dose constraints from trials of moderate hypofractionation.
Fig 2.
Fig 2.
Examples of two methods of rectal contouring. The attached example prescribed to 6,000 cGy in 20 fractions compares the two methods of contouring the rectum in (A) the axial plane, (B) sagittal plane, and (C) representative DVH. The rectal sparing appears to be much greater using the CHHiP/RTOG 0415 method (orange) compared to the PROFIT method (yellow). If the CHHiP/RTOG 0415 contouring method were used with the PROFIT constraints, the rectum may be allowed to receive a greater dose than allowed on the PROFIT trial.
Fig 3.
Fig 3.
(A) Rectal dose constraints from trials of ultrahypofractionation. (B) Bladder dose constraints from trials of ultrahypofractionation.
See this image and copyright information in PMC

References

    1. Hamdy FC, Donovan JL, Lane JA, et al. : 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N Engl J Med 375:1415-1424, 2016 - PubMed
    1. Dearnaley DP, Khoo VS, Norman AR, et al. : Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: A randomised trial. Lancet 353:267-272, 1999 - PubMed
    1. Viani GA, Viana BS, Martin JE, et al. : Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial. Cancer 122:2004-2011, 2016 - PubMed
    1. Kupelian PA, Langen KM, Willoughby TR, et al. : Image-guided radiotherapy for localized prostate cancer: Treating a moving target. Semin Radiat Oncol 18:58-66, 2008 - PubMed
    1. Miralbell R, Roberts SA, Zubizarreta E, et al. : Dose-fractionation sensitivity of prostate cancer deduced from radiotherapy outcomes of 5,969 patients in seven international institutional datasets: α/β = 1.4 (0.9-2.2) Gy. Int J Radiat Oncol Biol Phys 82:e17-e24, 2012 - PubMed