Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Oct 8;2018(10):rjy258.
doi: 10.1093/jscr/rjy258. eCollection 2018 Oct.

Synchronous malignant phyllodes tumour and invasive lobular carcinoma-case report and review

Henry To  1 , Bee Shan Ong  1 , Tom Dodd  2 , Subhita Prasannan  1
Affiliations
Case Reports

Synchronous malignant phyllodes tumour and invasive lobular carcinoma-case report and review

Henry To et al. J Surg Case Rep. .

Abstract

Synchronous phyllodes tumour and invasive lobular carcinoma is an extremely rare event. We report these concurrent diagnoses in a patient observed in an ipsilateral breast, suspected due to breast risk factors (family history and lobular carcinoma in situ) and the presence of malignant phyllodes. Screening breast magnetic resonance imaging was able to identify the carcinoma which was occult in other imaging. An understanding of the possibility of dual diagnoses may lead to additional investigations for its identification. Treatment may then be tailored to the individual's pathology.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
(a) Right mammogram cranial–caudal and (b) medial lateral oblique views showing the 65 mm phyllodes tumour; and (c) MRI T1 views with post-surgical wide local excision cavity and synchronous lobular carcinoma (labelled by orange arrow).
Figure 2:
Figure 2:
High power (×400) photomicrographs of Haematoxylin and Eosin stained slides showing (a) malignant phyllodes with infiltration beyond its margin to the breast fat, (b) lobular carcinoma in situ in margin next to malignant phyllodes and (c) lobular carcinoma with lobular carcinoma in situ.
See this image and copyright information in PMC

References

    1. Telli ML, Horst KC, Guardino AE, Dirbas FM, Carlson RW. Phyllodes tumors of the breast: natural history, diagnosis, and treatment. J Natl Compr Canc Netw 2007;5:324–30. - PubMed
    1. Lakhani S, Ellis I, Schnitt S, Tan P, Van de Vijver M. World Health Organisation Classification of Tumors of the Breast. Lyon, France: International Agency for Research on Cancer (IARC), 2012.
    1. Neto GB, Rossetti C, Souza NA, Fonseca FL, Azzalis LA, Junqueira VBC, et al. . Coexistence of benign phyllodes tumor and invasive ductal carcinoma in distinct breasts: case report. Eur J Med Res 2012;17:8. - PMC - PubMed
    1. Potdevin LB, Alsaati G, Sidawy M, Tousimis EA. Management of synchronous phyllodes tumors with invasive breast carcinoma: a review of the literature and a case report breast. Canc Treat Res Commun 2016;9:134–8.
    1. Kodama T, Kameyama K, Mukai M, Sugiura H, Ikeda T, Okada Y. Invasive lobular carcinoma arising in phyllodes tumor of the breast. Virchows Archiv 2003;442:614–6. - PubMed

Publication types