Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct;13(5):1111-1120.
doi: 10.1111/eip.12741. Epub 2018 Oct 12.

Latent profile analysis of psychosis liability in a community-derived sample of adolescents: Links with mental health difficulties, suicidal ideation, bipolar-like experiences and psychotic-like experiences

Eduardo Fonseca-Pedrero  1   2   3 , Javier Ortuño-Sierra  1   3 , José Muñiz  2   4 , Julio Bobes  2   5
Affiliations

Latent profile analysis of psychosis liability in a community-derived sample of adolescents: Links with mental health difficulties, suicidal ideation, bipolar-like experiences and psychotic-like experiences

Eduardo Fonseca-Pedrero et al. Early Interv Psychiatry. 2019 Oct.

Abstract

Aim: The main goal of the present study was to explore the latent structure of schizotypy as an indicator of psychosis liability, in a community-derived sample of adolescents. Links to mental health difficulties, prosocial behaviour, suicidal ideation, bipolar-like experiences and psychotic-like experiences (PLEs) (severity and distress) were compared across schizotypy latent profiles.

Method: The present research included 1588 adolescents selected by a stratified random cluster sampling. The Oviedo Schizotypy Assessment Questionnaire (ESQUIZO-Q), The Paykel Suicide Scale (PSS), The Strengths and Difficulties Questionnaire (SDQ), The Prodromal Questionnaire-Brief (PQ-B), The Mood Disorder Questionnaire (MDQ), The Penn Matrix Reasoning Test (PMRT), The Family Affluence Scale-II (FAS-II), and The Oviedo Infrequency Scale (INF-OV) were used.

Results: Using latent profile analysis four latent classes (LC) were identified: "Positive schizotypy" (14.1%, n = 224), "Low schizotypy" (51.9%, n = 825), "Social Disorganization schizotypy" (27.2%, n = 432), and "High schizotypy" (6.7%, n = 107). The "High schizotypy" class scored higher on several psychometric indicators of psychopathology (ie, mental health difficulties, suicide ideation, bipolar-like experiences and PLEs) relative to the other three LC.

Conclusion: Four groups of adolescents with different patterns of schizotypal traits and different clinical-pathological meaning were found. Deficits found across schizotypy latent profiles, resembling those found in patients with psychosis and ultra-high risk samples. The identification of homogeneous subgroups of adolescents potentially at risk for psychosis may help us in the prevention of psychotic-spectrum disorders and mental health problems.

Keywords: adolescents; latent profile; psychosis; risk; schizotypal; schizotypy.

PubMed Disclaimer

References

REFERENCES

    1. Ahmed, A. O., Buckley, P. F., & Mabe, P. A. (2012). Latent structure of psychotic experiences in the general population. Acta Psychiatrica Scandinavica, 125(1), 54-65. https://doi.org/10.1111/j.1600-0447.2011.01800.x
    1. Akaike, H. (1987). Factor analysis and AIC. Psychometrika, 52, 317-332.
    1. Arango, C., Díaz-Caneja, C., McGorry, P., Rapoport, J., Sommer, I., Vorstman, J., … Carpenter, W. (2018). Preventive strategies for mental health. Lancet Psychiatry, 5, 591-604.
    1. Barrantes-Vidal, N., Fañanás, L., Rosa, A., Caparrós, B., Riba, M. D., & Obiols, J. E. (2002). Neurocognitive, behavioral and neurodevelopmental correlates of schizotypy clusters in adolescents from the general population. Schizophrenia Research, 61(2), 293-302.
    1. Barrantes-Vidal, N., Grant, P., & Kwapil, T. (2015). The role of schizotypy in the study of the etiology of schizophrenia spectrum disorders. Schizophrenia Bulletin, 41, S408-S416.

Publication types