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Meta-Analysis
. 2018 Oct 12;13(10):e0202987.
doi: 10.1371/journal.pone.0202987. eCollection 2018.

The prognostic value of prognostic nutritional index in hepatocellular carcinoma patients: A meta-analysis of observational studies

Zhiling Wang  1 , Jie Wang  1 , Peijun Wang  2
Affiliations
Meta-Analysis

The prognostic value of prognostic nutritional index in hepatocellular carcinoma patients: A meta-analysis of observational studies

Zhiling Wang et al. PLoS One. .

Retraction in

Abstract

Background and aims: The clinical value of the prognostic nutritional index (PNI) in hepatocellular carcinoma (HCC) has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between PNI and HCC prognosis.

Method: PubMed, EMBASE, Web of Science databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to determine the prognostic and clinic-pathological values of PNI in HCC patients. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted to estimate the association of PNI with survival and clinic-pathological characteristics, respectively.

Results: A total of eleven studies involving 3165 patients were analyzed. The pooled results indicated that low PNI is a significant predictor of poor 1-year, 3-year, 5-year OS (OR, 2.91, 4.05, 3.65; 95%CI, 2.30 to 3.70, 3.27 to 5.03,2.96-4.50; P = 0.14,0.22,0.11 respectively) and disease-free survival (DFS) (OR,2.35, 2.57, 2.75; 95%CI, 1.71 to 3.23, 1.89 to 3.49,2.01 to 3.75; P = 0.39,0.04,0.11, respectively). Moreover, PNI is significantly associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients. However, PNI is not significantly associated with tumor number and the incidence of cirrhosis in HCC patients.

Conclusions: PNI is an independent predictive indicator of survival and associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients.

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132(7):2557–76. 10.1053/j.gastro.2007.04.061 - DOI - PubMed
    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. 10.3322/caac.20107 - DOI - PubMed
    1. Schuppan D, Afdhal NH. Liver cirrhosis. Lancet 2008; 371: 838–51. 10.1016/S0140-6736(08)60383-9 - DOI - PMC - PubMed
    1. Berasain C, Castillo J, Perugorria MJ et al. (2009) Inflammation and liver cancer: new molecular mechanisms.Ann N Y Acad Sci; 1155:206–221 10.1111/j.1749-6632.2009.03704.x - DOI - PubMed
    1. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005;42:1208–36. 10.1002/hep.20933 - DOI - PubMed