Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency

Harry Sokol¹, Nizar Mahlaoui², Claire Aguilar³, Perrine Bach⁴, Olivier Join-Lambert⁵, Aurélie Garraffo⁶, Philippe Seksik⁷, François Danion⁶, Sarah Jegou⁸, Marjolene Straube⁸, Christelle Lenoir⁹, Bénédicte Neven¹⁰, Despina Moshous¹⁰, Stéphane Blanche¹¹, Bénédicte Pigneur¹², Olivier Goulet¹², Frank Ruemmele¹², Felipe Suarez¹³, Laurent Beaugerie¹⁴, Stéphanie Pannier¹⁵, Françoise Mazingue¹⁶, Olivier Lortholary¹⁷, Lionel Galicier¹⁸, Capucine Picard¹⁹, Geneviève de Saint Basile²⁰, Sylvain Latour²¹, Alain Fischer²²

Affiliations

¹ Sorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, Assistance Publique Hôpitaux de Paris (APHP), Laboratoire des Biomolécules (LBM), rue de Chaligny, Paris, France; INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, France; Department of Gastroenterology, Saint Antoine Hospital, AP-HP, UPMC Univ. Paris 06, Paris, France; French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France.
² French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France.
³ Infectious Diseases and Tropical Medicine Department Paris Descartes University, Necker-Pasteur Infectious Diseases Center, Necker-Enfants Malades Hospital APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France.
⁴ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France.
⁵ Microbiology Department, Paris Descartes University, Necker-Enfants Malades Hospital, APHP, Paris, France.
⁶ Infectious Diseases and Tropical Medicine Department Paris Descartes University, Necker-Pasteur Infectious Diseases Center, Necker-Enfants Malades Hospital APHP, Paris, France.
⁷ Sorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, Assistance Publique Hôpitaux de Paris (APHP), Laboratoire des Biomolécules (LBM), rue de Chaligny, Paris, France; Department of Gastroenterology, Saint Antoine Hospital, AP-HP, UPMC Univ. Paris 06, Paris, France.
⁸ Sorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, Assistance Publique Hôpitaux de Paris (APHP), Laboratoire des Biomolécules (LBM), rue de Chaligny, Paris, France.
⁹ INSERM UMR 1163, Imagine Institute, Paris, France.
¹⁰ Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France.
¹¹ Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France.
¹² INSERM UMR 1163, Imagine Institute, Paris, France; Paediatric Gastroenterology Hepatology and Nutrition Department, Paris Descartes University, Hôpital Necker-Enfants Malades, APHP, Paris, France.
¹³ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Hematology Department, Paris Descartes University, Necker-Enfants Malades University Hospital, APHP, Paris, France.
¹⁴ Department of Gastroenterology, Saint Antoine Hospital, AP-HP, UPMC Univ. Paris 06, Paris, France.
¹⁵ Study Center for Primary Immunodeficiencies, Necker-Enfants Malades University Hospital, APHP, Paris, France; Department of Orthopedic Pediatrics, Necker-Enfants Malades University Hospital, APHP, Paris, France.
¹⁶ Department of Pediatrics, Hôpital Jeanne de Flandre, University Hospital of Lille, Lille, France.
¹⁷ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; Infectious Diseases and Tropical Medicine Department Paris Descartes University, Necker-Pasteur Infectious Diseases Center, Necker-Enfants Malades Hospital APHP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France.
¹⁸ Department of Clinical Immunology, Saint-Louis Hospital, APHP, Paris, France.
¹⁹ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France; Study Center for Primary Immunodeficiencies, Necker-Enfants Malades University Hospital, APHP, Paris, France.
²⁰ INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France; Study Center for Primary Immunodeficiencies, Necker-Enfants Malades University Hospital, APHP, Paris, France.
²¹ INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France.
²² French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France; Collège de France, Paris, France. Electronic address: alain.fischer@aphp.fr.

PMID: 30312711
DOI: 10.1016/j.jaci.2018.09.021

Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency

Harry Sokol et al. J Allergy Clin Immunol. 2019 Feb.

. 2019 Feb;143(2):775-778.e6.

doi: 10.1016/j.jaci.2018.09.021. Epub 2018 Oct 10.

Authors

Affiliations

¹ Sorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, Assistance Publique Hôpitaux de Paris (APHP), Laboratoire des Biomolécules (LBM), rue de Chaligny, Paris, France; INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, France; Department of Gastroenterology, Saint Antoine Hospital, AP-HP, UPMC Univ. Paris 06, Paris, France; French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France.
² French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France.
³ Infectious Diseases and Tropical Medicine Department Paris Descartes University, Necker-Pasteur Infectious Diseases Center, Necker-Enfants Malades Hospital APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France.
⁴ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France.
⁵ Microbiology Department, Paris Descartes University, Necker-Enfants Malades Hospital, APHP, Paris, France.
⁶ Infectious Diseases and Tropical Medicine Department Paris Descartes University, Necker-Pasteur Infectious Diseases Center, Necker-Enfants Malades Hospital APHP, Paris, France.
⁷ Sorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, Assistance Publique Hôpitaux de Paris (APHP), Laboratoire des Biomolécules (LBM), rue de Chaligny, Paris, France; Department of Gastroenterology, Saint Antoine Hospital, AP-HP, UPMC Univ. Paris 06, Paris, France.
⁸ Sorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, Assistance Publique Hôpitaux de Paris (APHP), Laboratoire des Biomolécules (LBM), rue de Chaligny, Paris, France.
⁹ INSERM UMR 1163, Imagine Institute, Paris, France.
¹⁰ Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France.
¹¹ Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France.
¹² INSERM UMR 1163, Imagine Institute, Paris, France; Paediatric Gastroenterology Hepatology and Nutrition Department, Paris Descartes University, Hôpital Necker-Enfants Malades, APHP, Paris, France.
¹³ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Hematology Department, Paris Descartes University, Necker-Enfants Malades University Hospital, APHP, Paris, France.
¹⁴ Department of Gastroenterology, Saint Antoine Hospital, AP-HP, UPMC Univ. Paris 06, Paris, France.
¹⁵ Study Center for Primary Immunodeficiencies, Necker-Enfants Malades University Hospital, APHP, Paris, France; Department of Orthopedic Pediatrics, Necker-Enfants Malades University Hospital, APHP, Paris, France.
¹⁶ Department of Pediatrics, Hôpital Jeanne de Flandre, University Hospital of Lille, Lille, France.
¹⁷ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; Infectious Diseases and Tropical Medicine Department Paris Descartes University, Necker-Pasteur Infectious Diseases Center, Necker-Enfants Malades Hospital APHP, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France.
¹⁸ Department of Clinical Immunology, Saint-Louis Hospital, APHP, Paris, France.
¹⁹ French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France; Study Center for Primary Immunodeficiencies, Necker-Enfants Malades University Hospital, APHP, Paris, France.
²⁰ INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France; Study Center for Primary Immunodeficiencies, Necker-Enfants Malades University Hospital, APHP, Paris, France.
²¹ INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France.
²² French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France; Collège de France, Paris, France. Electronic address: alain.fischer@aphp.fr.

PMID: 30312711
DOI: 10.1016/j.jaci.2018.09.021

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Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency

Affiliations

Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency

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