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Review
. 2018 Oct;97(41):e07689.
doi: 10.1097/MD.0000000000007689.

Association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy: Evidence from a meta-analysis

Yan Zhuang  1 , Fukun Niu  1 , Defeng Liu  1 , Juanjuan Sun  1 , Xiaowei Zhang  1 , Jian Zhang  2 , Shuxia Guo  1
Affiliations
Review

Association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy: Evidence from a meta-analysis

Yan Zhuang et al. Medicine (Baltimore). 2018 Oct.

Abstract

Background: Diabetic nephropathy (DN) is a common complication in patients with diabetic mellitus (DM). Growing evidences have demonstrated that the polymorphisms of angiotensin II receptor type 1 (AGTR1) showed significant association with DN onset, but no consensus has been achieved yet. Therefore, we performed this meta-analysis to combine the findings of previous researches for a more comprehensive conclusion.

Methods: Eligible publications were identified through electronic databases. The intensity of the correlation between AGTR1 A1166C polymorphism and DN susceptibility was evaluated through calculating pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs). Heterogeneity among included studies was examined with Q test. When P-value less than .05, significant heterogeneity presented, random-effects model was used to calculate the pooled ORs, otherwise, the fixed-effects model was used. Stratification analyses were also performed based on ethnicity and the type of DM.

Results: Seventeen eligible articles were finally included in the present meta-analysis. The analysis results showed that AGTR1 A1166C polymorphism was significantly related to increased risk of DN under CC versus AA (OR = 1.723, 95% CI = 1.123-2.644), CC + AC versus AA (OR = 1.179, 95% CI = 1.004-1.383), CC versus AA + AC (OR = 1.662, 95% CI = 1.112-2.486), and C versus A (OR = 1.208, 95% CI = 1.044-1.397) genetic models. Additionally, a similar result was also found in Asian and T2DM (type 2 diabetic mellitus) groups after subgroup analyses of ethnicity and DM type.

Conclusion: AGTR1 A1166C polymorphism may increase the susceptibility to DN, especially in Asians and T2DM population.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow diagram for the process of study selecting with detailed reasons for exclusion.
Figure 2
Figure 2
Forest plot for the association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy under CC + AC vs AA contrast after stratified by ethnicity.
Figure 3
Figure 3
Forest plot for the association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy under C vs A contrast after stratified analysis by DM type.
Figure 4
Figure 4
Begg funnel plot for publication bias under CC vs AA + AC genetic model.
See this image and copyright information in PMC

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