Technique Pinpoints Oncogenic BRCA1 Mutations
- PMID: 30314988
- DOI: 10.1158/2159-8290.CD-NB2018-128
Technique Pinpoints Oncogenic BRCA1 Mutations
Abstract
Researchers induced nearly 4,000 germline mutations in BRCA1 in human cells and tracked the effects. The results reveal that 21% of single-nucleotide variants they tested are likely oncogenic.
©2018 American Association for Cancer Research.
Comment on
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Accurate classification of BRCA1 variants with saturation genome editing.Nature. 2018 Oct;562(7726):217-222. doi: 10.1038/s41586-018-0461-z. Epub 2018 Sep 12. Nature. 2018. PMID: 30209399 Free PMC article.
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