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. 1987 Apr;326(6114):662-9.
doi: 10.1038/326662a0.

Genome organization and transactivation of the human immunodeficiency virus type 2

M Guyader, M Emerman, P Sonigo, F Clavel, L Montagnier, M Alizon

Genome organization and transactivation of the human immunodeficiency virus type 2

M Guyader et al. Nature. 1987 Apr.

Abstract

Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of limited sequence homology; this may help the determination of the structure-function relationships of the different viral elements.

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